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Highly Efficient Synthesis of Chiral β-Amino Acid Derivatives via Asymmetric Hydrogenation

2002; American Chemical Society; Volume: 4; Issue: 23 Linguagem: Inglês

10.1021/ol026935x

1523-7060

Wenjun Tang, Xumu Zhang,

Surface Chemistry and Catalysis

The Rh−TangPhos complex is an efficient hydrogenation catalyst for making chiral β-amino acid derivatives. With the Rh−TangPhos system, high enantioselectivities (up to 99.6%) and turnover numbers have been obtained in the hydrogenation of E/Z isomeric mixtures of both β-alkyl and β-aryl β-(acylamino)acrylates.