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PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans

2005; Springer Nature; Volume: 17; Issue: 4 Linguagem: Inglês

10.1038/sj.ijir.3901325

1476-5489

Carlo Foresta, Andrea Lana, Anna Cabrelle, M Ferigo, Nicola Caretta, Andrea Garolla, Giorgio Palù, Alberto Ferlin,

Histone Deacetylase Inhibitors Research

Bone marrow-derived endothelial progenitor cells (EPCs) originate from haematopoietic stem cells in bone marrow and migrate into the peripheral circulation to promote endothelial repair and neovascularization. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The aim of our study was to determine the number of these cells in healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a significant increase in the number of these cells after the drug administration.