Forum Aminophylline reversal of diazepam sedation
1984; Wiley; Volume: 39; Issue: 8 Linguagem: Inglês
10.1111/j.1365-2044.1984.tb06530.x
ISSN1365-2044
AutoresS. Arvidsson, D Niemand, S. Martinell, B Ekström-Jodal,
Tópico(s)Nausea and vomiting management
ResumoSummary A double‐blind randomised study was performed to investigate whether aminophylline reversed the sedative effect of diazepam. Thirty‐two patients undergoing genito‐urinary surgery with spinal or topical anasthesia were given diazepam to maintain a state of deep sedation. Postoperatively patients received either aminophylline (60–120 mg) or physiological saline intravenously. The aminophylline group showed a rapid reversal of sedation. which persisted throughout the observation period of 2 hours. No such effect was seen in the patients who received saline and the difference was still obvious after 2 hours. It is concluded that aminophylline is a potent antagonist to the sedative effect of diazepam.
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