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Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

2014; National Academy of Sciences; Volume: 111; Issue: 25 Linguagem: Inglês

10.1073/pnas.1318731111

1091-6490

Anna Okhrimenko, Joachim R. Grün, Kerstin Westendorf, Zhuo Fang, Simon Reinke, Philipp von Roth, Georgi I. Wassilew, Anja A. Kühl, Robert Kudernatsch, Sonya Demski, Carmen Scheibenbogen, Koji Tokoyoda, Mairi McGrath, Martin Raftery, Günther Schönrich, Alessandro Serra, Hyun‐Dong Chang, Andreas Radbruch, Jun Dong,

Hematopoietic Stem Cell Transplantation

Significance Memory T cells are essential components of immunological memory. In the apparent absence of antigen, numbers of recirculating antigen-specific memory T cells dwindle, provoking the question of whether there is immunological memory without memory T cells. Here we show that human memory T cells can reside in the bone marrow as resting cells in terms of proliferation, transcription, and mobility. The repertoire of bone marrow memory T cells is enriched for systemic pathogens representing persistent, recent, and childhood challenges. In terms of absolute numbers, memory T cells specific for systemic antigens are maintained predominantly in the bone marrow, in particular those representing historic encounters.