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Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe

2001; National Academy of Sciences; Volume: 98; Issue: 15 Linguagem: Inglês

10.1073/pnas.121005598

1091-6490

Luther Davis, Gerald R. Smith,

Yeasts and Rust Fungi Studies

In most organisms homologous recombination is vital for the proper segregation of chromosomes during meiosis, the formation of haploid sex cells from diploid precursors. This review compares meiotic recombination and chromosome segregation in the fission yeast Schizosaccharomyces pombe and the distantly related budding yeast Saccharomyces cerevisiae, two especially tractable microorganisms. Certain features, such as the occurrence of DNA breaks associated with recombination, appear similar, suggesting that these features may be common in eukaryotes. Other features, such as the role of these breaks and the ability of chromosomes to segregate faithfully in the absence of recombination, appear different, suggesting multiple solutions to the problems faced in meiosis.