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Soluble CD163: a marker molecule for monocyte/macrophage activity in disease

2002; Taylor & Francis; Volume: 62; Issue: 7 Linguagem: Inglês

10.1080/003655102762377466

1502-7686

Holger Jon Møller, Johannes M. F. G. Aerts, H. Grøbæk, Niels Anker Peterslund, P H Petersen, Nete Hornung, L. Renjmark, E. Jabbarpour, Søren K. Moestrup,

Erythrocyte Function and Pathophysiology

AbstractBy immunoprecipitation we have identified a soluble plasma form of CD163 (sCD163), the IL-6 inducible macrophage-receptor for clearing haptoglobinhaemoglobin complexes. A sandwich ELISA for measuring sCD163 was established and used to determine the sCD163 levels in normal subjects and patients with inflammatory and myeloproliferative diseases. In normal subjects, the concentration of sCD163 was high (median 1.9 mg/l) with low intraindividual variation. Highly increased levels were seen in patients with sepsis, myeloid leukaemia and in patients with Gaucher disease characterized by accumulation of tissue macrophages. Although the physiological role of sCD163 remains unknown, our present data suggest that sCD163 might prove to be a valuable marker molecule in infectious and myeloproliferative diseases.KeywordsAssay ValidationCd163ElisaGaucher DiseaseInfectionHaemoglobin Scavenger ReceptorHaptoglobinHbsrInflammationLeukaemiaM130MacrophagePlasma Measurement