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Alzheimer's Disease and Down's Syndrome*

1982; Wiley; Volume: 396; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1982.tb26850.x

1749-6632

Donald L. Price, Peter J. Whitehouse, Robert G. Struble, Joseph T. Coyle, Arthur W. Clark, Mahlon R. DeLong, Linda C. Cork, John C. Hedreen,

Aluminum toxicity and tolerance in plants and animals

Annals of the New York Academy of SciencesVolume 396, Issue 1 p. 145-164 Alzheimer's Disease and Down's Syndrome* DONALD L. PRICE, DONALD L. PRICE Department of Pathology, Department of Neurology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorPETER J. WHITEHOUSE, PETER J. WHITEHOUSE Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorROBERT G. STRUBLE, ROBERT G. STRUBLE Department of Pathology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorJOSEPH T. COYLE, JOSEPH T. COYLE Departments of Neuroscience, Psychiatry and Pharmacology and Experimental Therapy The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorARTHUR W. CLARK, ARTHUR W. CLARK Department of Pathology, Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorMAHLON R. DELONG, MAHLON R. DELONG Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorLINDA C. CORK, LINDA C. CORK Department of Pathology, Division of Comparative Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorJOHN C. HEDREEN†, JOHN C. HEDREEN† Department of Pathology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this author DONALD L. PRICE, DONALD L. PRICE Department of Pathology, Department of Neurology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorPETER J. WHITEHOUSE, PETER J. WHITEHOUSE Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorROBERT G. STRUBLE, ROBERT G. STRUBLE Department of Pathology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorJOSEPH T. COYLE, JOSEPH T. COYLE Departments of Neuroscience, Psychiatry and Pharmacology and Experimental Therapy The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorARTHUR W. CLARK, ARTHUR W. CLARK Department of Pathology, Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorMAHLON R. DELONG, MAHLON R. DELONG Department of Neurology The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorLINDA C. CORK, LINDA C. CORK Department of Pathology, Division of Comparative Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this authorJOHN C. HEDREEN†, JOHN C. HEDREEN† Department of Pathology, Neuropathology Laboratory The Johns Hopkins University School of Medicine Baltimore, Maryland 21205Search for more papers by this author First published: October 1982 https://doi.org/10.1111/j.1749-6632.1982.tb26850.xCitations: 71 * This research was supported by National Institutes of-Health Grants NS 10580, NS 15721, NS 07179, and MH 26654. Drs. Cork and Coyle are both recipients of Research Career Development Awards, NS 00488 and MH OO125, respectively. 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The prevalence and malignancy of Alzheimer's disease: A major killer. Arch. Neurol. 33: 217– 218. 6 Wang, H.S. 1977. Dementia of old age. In Aging and Dementia. W.L. Smith & M. Kinsborn, Eds.: 1– 24. Spectrum. New York . 7 Wisniewski, K., J. Howe, D.G. Williams & H.M. Wisniewski. 1978. Precocious aging and dementia in patients with Down's syndrome. Biol. Psychiatry 13: 619– 627. 8 Burger, P.C. & F.S. Vogel. 1973. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am. J. Pathol. 73: 457– 476. 9 Wisniewski, H.M. & R.D. Terry. 1973. Morphology of the aging brain, human and animal. In Progress in Brain Research. D.H. Ford, Ed. 40: 167– 186. Elsevier Scientific Publishing Company. Amsterdam . 10 Ellis, W.G., J.R. McCullogh & C.L. Corley. 1974. Presenile dementia in Down's syndrome: Ultrastructural identity with Alzheimer's disease. Neurology 24: 101– 106. 11 Hooper, W.M. & F.S. Vogel. 1976. The limbic system in Alzheimer's disease: Neuropathological investigation. Am. J. Pathol. 85: 1– 13. 12 Wisniewski, H.M. & R.D. Terry. 1976. Neuropathology of the aging brain. In Neurobiology of Aging (Aging). R.D. Terry & S. Gershon, Eds. 3: 265– 280. Raven Press. New York . 13 Terry, R.D. & P. Davies. 1980. Dementia of the Alzheimer type. Ann. Rev. Neurosci. 3: 77– 95. 14 Ropper, A.H. & R.S. Williams. 1980. Relationship between plaques, tangles, and dementia in Down syndrome. Neurology 30: 639– 644. 15 Wisniewski, H.M. & K. Iqbal. 1980. Aging of the brain and dementia. Trends Neurosci. 3: 226– 228. 16 Davies, P. & A.J.R. Maloney. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403. 17 Perry, E.K., R.H. Perry, G. Blessed & B.E. Tomlinson. 1977. Neurotransmitter enzyme abnormalities in senile dementia. J. Neurol. Sci. 34: 247– 265. 18 White, P., M.J. Goodhardt, J.P. Keet, C.R. Hiley, L.H. Carrasco, I.E.I. Williams & D.M. Bowen. 1977. Neocortical cholinergic neurons in elderly people. Lancet 1: 668– 670. 19 Reisine, T.D., H.I. Yamamura, E.D. Bird, E. Spokes & S.J. Enna. 1978. Pre- and postsynaptic neurochemical alterations in Alzheimer's disease. Brain Res. 159: 477– 481. 20 Davies, P. 1979. Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res. 171: 319– 327. 21 Whitehouse, P.J., D.L. Price, A.W. Clark, J.T. Coyle & M.R. Delong. 1981. Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10: 122– 126. 22 Whitehouse, P.J., D.L. Price, R.G. Struble, A.W. Clark, J.T. Coyle & M.R. Delong. 1982. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 215: 1237– 1239. 23 White, C.L., J.C. Hedreen, P.J. Whitehouse & D.L. Price. The dementia of Down syndrome: Evidence for a lesion in the basal forebrain. In preparation. 24 Tomlinson, B.E. 1977. The pathology of dementia. In Dementia, 2nd edition. C.E. Wells, Ed.: 113– 153. F.A Davis. Philadelphia . 25 Johnson, R.T., R. Katzman, E. Shooter, E. McGeer, D. Silberberg & D. Price. 1979. Report of the Panel on Inflammatory, Demyelinating, and Degenerative Diseases to the National Advisory Neurological and Communicative Disorders and Stroke Council. 1979. U.S. Department of Health, Education, and Welfare. Public Health Service NIH Publication 79–1916. National Institutes of Health. Bethesda, MD. 26 Constantinidis, J. 1978. Is Alzheimer's disease a major form of senile dementia? Clinical, anatomical and genetic data. In Alzheimer's Disease: Senile Dementia and Related Disorders (Aging). R. Katzman, R.D. Terry & K.L. Bick, Eds. 7: 15– 27. Raven Press. New York . 27 Corsellis, J.A.M. 1976. Ageing and the dementias. In Greenfield's Neuropathology. W. Blackwood & H.A.N. Corsellis, Eds.: 796– 848. Edward Arnold. London . 28 Powers, J.M. & S.S. Spicer. 1978. Histochemical similarity of senile plaque amyloid to apudamyloid. Virchows Arch. A. 376: 107– 115. 29 Glenner, G.G. 1980. Amyloid deposits and amyloidosis. The β-fibriloses. New Engl. J. Med. 302: 1283– 1292 & 1333–1343. 30 Terry, R.D. 1980. Structural changes in senile dementia of the Alzheimer type. In Aging of the Brain and Dementia (Aging). L. Amaducci, A.N. Davison & P. Antuono, Eds. 13: 13– 32. Raven Press. New York . 31 Powers, J.M., W.W. Schlaepfer, M.C. Willingham & B.J. Hall. 1981. An immunoperoxidase study of senile cerebral amyloid. J. Neuropathol. Exp. Neurol. 40: 311. 32 Kidd, M. 1963. Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 197: 192– 193. 33 Hirano, A. & H.M. Zimmerman. 1962. Alzheimer's neurofibrillary changes: a topographic study. Arch. Neurol. 7: 227– 242. 34 Ishii, T. 1965. Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia. Acta Neuropathol. 6: 181– 189. 35 Ball, M.J. 1978a. Neuronal loss, neurofibrillary tangles, and granulovacuolar degeneration in the hippocampus with aging and dementia. Acta Neuropathol. 37: 111– 118. 36 Ball, M.J. 1978b. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in the hippocampal cortex of aging and demented patients: A quantitative study. Acta Neuropathol. 42: 73– 80. 37 Kemper, T.L. 1978. Senile dementia: A focal disease in the temporal lobe. In Senile Dementia: A Biomedical Approach, Developments in Neuroscience. K. Nandy, Ed. 3: 105– 113. Elsevier-North Holland. New York . 38 Perry, E.K., B.E., Tomlinson, G. Blessed, K. Bergman, P.H. Gibson & R.H. Perry. 1978. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. 2: 1457– 1459. 39 Ball, M.J. 1972. Neurofibrillary tangles and the pathogenesis of dementia: A quantitative study. Neuropathol. Appl. Neurobiol. 2: 395– 410. 40 Shefer, V.F. 1972. Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's diseases. Zh. Neuropathol. Psikhiatr. 72: 1024– 1029. 41 Ball, M.J. 1978c. Histotopography of cellular changes in Alzheimer's disease. In Senile Dementia: A Biomedical Approach. Developments in Neuroscience. K. Nandy, Ed. 3: 89– 104. Elsevier North-Holland. New York . 42 Herzog, A.G. & T.L. Kemper. 1980. Amygdaloid changes in aging and dementia. Arch. Neurol. 37: 625– 629. 43 Colon, E.J. 1973. The cerebral cortex in presenile dementia, a quantitative analysis. Acta Neuropathol. (Berlin) 23: 281– 290. 44 Brody, H. 1955. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J. Comp. Neurol. 102: 511– 556. 45 Brody, H. 1978. Cell counts in cerebral cortex and brainstem. In Alzheimer's Disease: Senile Dementia and Related Disorders (Aging). R. Katzman, R.D. Terry & K.L. Bick, Eds. 7: 345– 351. Raven Press. New York . 46 Terry, R.D. 1979. Morphological changes in Alzheimer's disease. In Senile Dementia: Ultrastructural Changes and Quantitative Studies in Congenital and Acquired Cognitive Disorders. R. Katzman, Ed.: 99– 105. Raven Press. New York . 47 Henderson, G., B.E. Tomlinson & P.H. Gibson. 1980. Cell counts in human cerebral cortex in normal adults throughout life using an image analyzing computer. J. Neurol. Sci. 46: 113– 136. 48 Terry, R.D., A. Peck, R. Deteresa, R. Schechter & D.S. Horoupian. 1981. Some morphometric aspects of the brain in senile dementia of the Alzheimer's type. Ann. Neurol. 10: 184– 192. 49 Drachman, D.A. & J. Leavitt. 1974. Human memory and the cholinergic system. A relationship to aging Arch. Neurol. 30: 113– 121. 50 Drachman, D.A. 1978. Memory, dementia, and the cholinergic system. In Alzheimer's Disease: Senile Dementia and Related Disorders (Aging). R. Katzman, R.D. Terry & K.L. Bick, Eds. 7: 141– 148. Raven Press. New York . 51 Butcher, L.L., K. Talbot & L. Bilezikjian. 1975. Acetylcholinesterase neurons in dopamine-containing regions of the brain. J. Neurol. Transm. 37: 127– 153. 52 Kuhar, M.J. 1976. The anatomy of cholinergic neurons. In Biology of Cholinergic Function. A.M. Goldberg & I. Hanin, Eds.: 3– 27. Raven Press. New York . 53 Lewis, P.R. & C.C.D. Shute. 1978. Cholinergic pathways in the CNS. In Chemical Pathways in the Brain, Handbook of Psychopharmacology. L.L. Iversen, S.D. Iversen & F.H. Snyder, Eds. 9: 315– 356. Plenum Press. New York . 54 Lehmann, J. & H.C. Fibiger. 1979. Acetylcholinesterase and the cholinergic neuron. Life Sci. 25: 1939– 1947. 55 Pope, A., H.H. Hess & E. Lewin. 1965. Microchemical pathology of the cerebral cortex in presenile dementias. Trans. Am. Neurol. Assoc. 89: 15– 16. 56 Bowen, D.M., C.B. Smith, P. White & A.N. Davison. 1976. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99: 459– 495. 57 Davies, P., R. Katzman & R.D. Terry. 1980. Reduced somatpstatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementia. Nature 288: 279– 280. 58 Hebb, CO., K. Krnjevic & A. Silver. 1963. Effect of undercutting on the acetylcholinesterase and choline acetyltransferase activity in the cat cerebral cortex. Nature (London) 198: 692. 59 Krnjevic, K. & K. A. Silver. 1965. A histochemical study of cholinergic fibers in the cerebral cortex. J. Anat. 99: 711– 759. 60 Shute, C.C.D. & P.R. Lewis. 1967. The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections. Brain 90: 497– 520. 61 Emson, P.C. & O. Lindvall. 1979. Distribution of putative neurotransmitters in the neocortex. Neuroscience 4: 1– 30. 62 Kelly, P.H. & K.E. Moore. 1978. Decrease of neocortical choline acetyltransferase after lesion of the globus pallidus in the rat. Exp. Neurol. 61: 479– 484. 63 Johnston, M.V., M. McKinney & J.T. Coyle. 1979. Evidence for a cholinergic projection to neocortex from neurons in the basal forebrain. Proc. Natl. Acad. Sci. USA 76: 5392– 5396. 64 Lehmann, J., J.I. Nagy, S. Atmadja & H.C. Fibiger. 1980. The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat. Neuro-science 5: 1161– 1174. 65 Coyle, J.T., M. McKinney & M.V. Johnston. 1981. Cholinergic innervation of the cerebral cortex: Implications for the pathophysiology of senile dementia of the Alzheimer's type. In Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders (Aging). S.J. Enna, T. Samorajski & B. Beer, Eds. 17: 149– 161. Raven Press. New York . 66 Johnston, M.V., M. McKinney & J.T. Coyle. 1981. Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat. Exp. Brain Res. 43: 159– 172. 67 Mesulam, M.M. & G.W. Van Hoesen. 1976. Acetylcholinesterase-rich projections from the basal forebrain of th Rhesus monkey to neocortex. Brain Res. 109: 152– 157. 68 Parent, A., L.J. Poirier, R. Boucher & L.L. Butcher. 1977. Morphological characteristics of acetylcholinesterase-containing neurons in the CNS of DF P-treated monkeys. II. Diencephalic medial telencephalic structures. J. Neurol. Sci. 32: 9– 28. 69 McKinney, M., R.G. Struble, J.T. Coyle & D.L. Price. Monkey nucleus basalis is enriched with choline acetyltransferase. J. Neurosci. In press. 70 Tomlinson, B.E., G. Blessed & M. Roth. 1968. Observations on the brains of nondemented old people. J. Neurol. Sci. 7: 331. 71 Wisniewski, H.M., B. Ghetti & R.D. Terry. 1973. Neurtic (senile) plaques and filamentous changes in aged rhesus monkeys. J. Neuropathol. Exp. Neurol. 32: 566– 584. 72 Struble, R.G., L.C. Cork, P.J. Whitehouse & D.L. Price. Cholinergic innervation in neuritic plaques. Science 216: 413– 415. 73 Davis, R.T. 1978. Old monkey behavior. Exp. Gerontol. 13: 237– 250. 74 Grittin, J.W. & D.L. Price. 1976. Axonal transport in motor neuron pathology. In Amyotrophic Lateral Sclerosis: Recent Research Trends. J. Andrews & R. Johnson, Eds.: 33– 67. Academic Press. New York . 75 Spencer, P.S. & H.H. Schaumburg. 1977. Ultrastructural studies of the dying-back process. IV. Differential vulnerability of PNS and CNS fibers in experimental central-peripheral distal axonopathies. J. Neuropathol. Exp. Neurol. 36: 300– 320. 76 Down, J.L.H. 1866. Observations on an ethnic classification of idiots. London Hospital Rep. 3: 259– 262. 77 Penrose, L.S. & G.F. Smith. 1966. Down's Anomaly. Little, Brown and Co. Boston . 78 Zellweger, H. 1977. Down syndrome. In Congenital Malformations of the Brain and Skull, Part II. P.J. Vinken & G.W. Bruyn, Eds. 31: 367– 469. North Holland Publishing Company. Amsterdam . 79 Hook, E.B. 1981. Down's syndrome: Frequency in human populations and factors pertinent to variation in rates. In Trisomy 21 (Down's Syndrome). F.F. Dela Cruz & P.S. Gerald, Eds.: 3– 68. University Park Press. Baltimore . 80 Heller, J.H. 1969. Human chromosome abnormalities as related to physical and mental dysfunction. J. Heredit. 60: 239. 81 Solitare, G. & J. Lamarche. 1966. Alzheimer disease and senile dementia as seen in mongoloids: Neuropathological observations. Am. J. Ment. Dis. 70: 840– 848. 82 Crapper, D.R., A.J. Dalton, M. Skopitz, P. Eng, J.H. Scott & V. Hachimski. 1975. Alzheimer degeneration in Down's syndrome. Electrophysiologic alterations and histopathologic findings. Arch. Neurol. 32: 618– 623. 83 Johnson, R.C. & R.B. Abelson. 1968. Intellectual, behavioral, and physical characteristics with trisomy, translocation, and mosiac types of Down's syndrome. Am. J. Ment. Defic. 73: 852– 855. 84 Smith, G.F. & J.M. Berg. 1976. Downs Anomaly, 2nd edit. Churchill Livingstone. Edinburgh . 85 Veall, R.M. 1974. The prevalence of epilepsy among mongols related to age. J. Ment. Defic. Res. 18: 99– 106. 86 Ellingson, R.J., J.D. Eisen & G. Ottersberg. 1973. Clinical electroencephalographic observations on institutionalized mongoloids confirmed by karyotype. In Handbook of EEG and Clinical Neurophysiology. A. Remond, Ed. 34: 193– 196. Elsevier. Amsterdam . 87 Loesch-Modzewski, I.D. 1968. Some aspects of the neurology of Down's syndrome. J. Ment. Dis. Res. 12: 237. 88 Dalton, A.J., D.R. Crapper & G.R. Schlotterer. 1974. Alzheimer's disease in Down's syndrome: Visual retention deficits. Cortex 10: 366– 377. 89 Benda, C.E. 1969. Down's Syndrome, 2nd ed. Grune & Stratton. New York . 90 Malamud, N. 1973. Neuropathology of organic brain syndromes associated with aging. In Advances in Behavioral Biology. C.M. Gaitz, Ed. 3: 63– 87. Plenum Press. New York . 91 Crome, L. & J. Stern. 1972. Pathology of Mental Retardation.: 200– 224. Williams & Wilkins. Baltimore . 92 Crome, L., V. Cowie & E. Slayer. 1966. A statistical note on cerebellar and brainstem weight in mongolism. J. Ment. Defic. Res. 10: 69– 72. 93 Davidoff, L. M. 1928. The brain in mongolian idiocy. Arch. Neurol. Psychiatr. 20: 1229– 1257. 94 Galaburda, A.M. & T.L. Kemper. 1979. Down syndrome: Is there a missing population of neurons Neurology 29: 569– 570. 95 Purpura, D.P. 1975. Normal and aberrant neuronal development in the cerebral cortex of human fetus and young infant. In Brain Mechanisms and Mental Retardation. N.A. Buchwald & M.A.B. Brazier, Eds.: 141– 169. Academic Press. New York . 96 Marin-Padilla, M. 1976. Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study. J. Comp. Neurol. 167: 63– 82. 97 Purpura, D.P. 1979. Pathobiology of cortical neurons in metabolic and unclassified dementias. In Congenital and Acquired Cognitive Disorders. R. Katzman, Ed.: 43– 68. Raven Press. New York . 98 Ribak, C.E. 1978. Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase. J. Neurocytol. 7: 461– 478. 99 Ribak, C.E., A.B. Harris, J.E. Vaughn & E. Roberts. 1979. Inhibitory GABAergic nerve terminals decrease at sites of focal epilepsy. Science 205: 211– 213. 100 Schochet, S.S. Jr. & P.W. Lampert & W.F. McCormick. 1973. Neurofibrillary tangles in patients with Down's syndrome: The light and electron microscopic study. Acta Neuropathol. 23: 342– 346. 101 Ball, M.J. & K. Nuttal. 1981. Topography of neurofibrillary tangles and granulovacuoles in hippocampi of patients with Downs sydrome: Quantitative comparison with normal ageing and Alzheimer's disease. Neuropathol. Appl. Neurobiol. 7: 13– 20. 102 Yates, C.M., J. Simpson, A.F.J. Maloney, A. Gordon & A.H. Reid. 1980. Alzheimer-like cholinergic deficiency in Down syndrome. Lancet 2: 979. 103 McCoy, E.E., M.J. Rostafinski & C. Fishburn. 1968. The concentration of serotonin by platelets in Down's syndrome. J. Ment. Defic. Res. 12: 18– 21. 104 Benson, P.P. & J. Southgate. 1971. Diminished activity of platelet monoamine oxydase in Down's syndrome. Am. J. Hum. Genet. 23: 211– 214. 105 Bouillin, D.J. & R.A. O'Brien. 1971. Abnormalities of 5-hydroxytryptamine uptake and binding by blood platelets from children with Down's syndrome. J. Physiol. (Lond.) 212: 287– 292. 106 Lott, I.T., D.L. Murphy & T.N. Chase. 1972. Down's syndrome. Neurology 22: 967– 972. 107 Tu, J. & M.W. Partington. 1972. 5-Hydroxyindol levels in the blood, and CSF in Down's syndrome. Phenylketoneuria and severe mental retardation. Develop. Med. Child Neurol. 14: 457– 466. 108 Terneaux, J.P., J.F. Mattei, M. Faudon, M.C. Barrit, J.P. Ardissone & F. Giraud. 1979. Peripheral and central 5-hydroxytryptamine in Trisomy 21. Life Sci. 25: 2017– 2022. 109 Mann, D.M.A., J. Lincoln, P.O. Yates & C.M. Brennan. 1980. Monoamine metabolism in Down's syndrome. Lancet 2: 1366– 1367. 110 Wetterberg, L., K.H. Gustavson, M. Backstrom, S.B. Ross & O. Froden. 1972. Low dopamine-beta-hydroxylase activity in Down's syndrome. Clin. Genet. 3: 152– 153. 111 Enns, L. & E.E. McCoy. 1980. A study of gamma-aminobutyric acid uptake in normal and Down's syndrome platelets. Br. J. Pharmacol. 71: 553– 556. 112 Meynert, T. 1872. Vom Gehirn der Saugetiere. In Handbuch der Lehre von den Geweben des Menschen und Thiere. S. Strieker, Ed. 2: 694– 808. Engelmann. Leipzig . 113 Gorry, J.R. 1963. Studies on the comparative anatomy of the ganglion basale of Meynert. Acta Anat. 55: 51– 104. 114 Divac, I. 1975. Magnocellular nuclei of the basal forebrain project to neocortex, brain stem and olfactory bulb. Review of some functional correlates. Brain Res. 93: 385– 398. 115 Jones, E.G., H. Burton, C.B. Safer & L.W. Swanson. 1976. Midbrain, diencephalic and cortical relationships of the nucleus basalis of Meynert and associated structures in primates. J. Comp. Neurol. 167: 385– 420. 116 Parent, A., S. Gravel & A. Oliver. 1979. The extrapyramidal and limbic systems' relationship at the globus pallidus level: A comparative histochemical study in the rat, cat, and monkey. In Advances in Neurology. L.J. Poirer, T.L. Sourkes & P.J. Bedard, Eds. 24: 1– 11. Raven Press. New York . 117 Hedreen, J.C., R.G. Struble, P.J. Whitehouse & D.L. Price. The topography of the nucleus basalis of Meynert in the human brain. Submitted for publication. 118 Delong, M.R. 1971. Activity of pallidal neurons during movement. J. Neurophysiol. 34: 414– 427. 119 Krettek, J.E. & J.L. Price. 1978. Amygdaloid projections of subcortical structures within the basal forebrain and brainstem in the rat and cat. J. Comp. Neurol. 178: 225– 254. 120 Safer, C.B. & A.D. Loewy. 1980. Efferent connections of the parabrachial nucleus in the rat. Brain Res. 197: 291– 317. 121 Ottersen, O.P. 1980. Afferent connections to the amygdaloid complex of the rat and cat. II. Afferents from the hypothalamus and the basal telencephalon. J. Comp. Neurol. 194: 267– 289. 122 Price, J.L. & T.P.S. Powell. 1970. The afferent connections of the nucleus of the horizontal limb of the diagonal band. J. Anat. 107: 239– 256. 123 Segal, M. & S. Landis. 1974. Afferents to hippocampus of rats studied with retrograde transport of horseradish-peroxidase. Brain Res. 78: 1– 15. 124 Segal, M. 1977. Afferents to the entorhinal cortex of the rat studied by the methods of retrograde transport of horseradish peroxidase. Exp. Neurol. 57: 750– 765. 125 Beckstead, R.M. 1978. Afferent connections of the entorhinal area in the rat as demonstrated by retrograde cell-labelling with horseradish peroxidase Brain Res. 152: 249– 264. 126 Amaral, D.G. & W.M. Cowan. 1980. Subcortical afferents to the hippocampal formation in the monkey. J. Comp. Neurol. 189: 543– 591. 127 Kievit, J. & H.G.J.M. Kuypers. 1975. Basal forebrain and hypothalamic connections to frontal and parital cortex in the Rhesus monkey. Science 187: 660– 662. 128 Winfield, D.A., K.C. Gatter & T.P.S. Powell. 1975. Certain connections of the visual cortex of the monkey as shown by the use of horseradish peroxidase. Brain Res. 92: 456– 461. 129 McKinney, M., J.C. Hedreen & J.T. Coyle. Anatomical study of the innervation of the rat neocoftex and hippocampus by basal forebrain. In preparation. 130 Rossier, J. 1977. Choline acetyltransferase: A review with special reference to its cellular and subcellular localization. Int. Rev. Neurobiol. 20: 283– 337. 131 Rossier, J. 1981. Serum monospecificity: A prerequisite for reliable immunohistochemical localization of neuronal markers including choline acetyltransferase. Neuroscience 6: 989– 991. 132 Eng, L.S., C.T. Uyeda, L.P. Chao & F. Wolfgram. 1974. Antibody to bovine choline acetyltransferase and immunofluorescent localization of the enzyme in neurons. Nature 250: 243– 245. 133 Kahn, K.D., L.P. Chad & L.S. Forno. 1980. Immunhistochemical localization of choline acetyltransferase in the human cerebellum. Brain Res. 193: 165– 171. 134 Kimura, H., P.L. McGeer, J.H. Peng & E.G., McGeer. 1981. The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat. J. Comp. Neurol. 200: 151– 201. 135 Eckenstein, F., Y-A. Barde & Thoenen. 1981. Production of specific antibodies to choline acetyltransferase purified from pig brain. Neuroscience 6: 993– 1000. 136 Wenk, H., V. Bigl & U. Meyer. 1980. Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats. Brain Res. Rev. 2: 295– 316. 137 Struble, R.G., M. McKinney, J.C. Hedreen, P.J. Whitehouse, J.T. Coyle & D.L. Price. Human nucleus basalis is enriched with choline acetyltransferase. In preparation. 138 Ingram, D.K., E.D. London & C.L. Goodrick. 1981. Age and neurochemical correlates of radial maze performance in rats. Neurobiology of Aging 2: 41– 47. 139 Delong, M.R. & A.P. Georgopoulous. 1981. Motor functions of the basal ganglia. In Handbook of Physiology, The Nervous System II. V.B. Brooks, Ed.: 1017– 1061. The American Physiology Society. Bethesda , MD . 140 Rolls, E.T., M.K. Sanghera & A. Roper-Hall. 1979. The latency of activation of neurons in the lateral hypothalmus and substantia innominata during feeding in the monkey. Brain Res. 164: 121– 135. 141 Griffin, J.W., L.C. Cork, P.N. Hoffman & D.L. Price. Experimental models of motor neuron degeneration. In Peripheral Neuropathy, 2nd edition. P.J. Dyck, P.K. Thomas, E.H. Lambert & R. Bunge, Eds. W.B. Saunders. Philadelphia . In press. 142 Price, D.L., J.W. Griffin, P.N. Hoffman, L.C. Cork & P.S. Spencer. The response of motor neurons to injury and disease. In Peripheral Neuropathy, 2nd edition. P.J. Dyck, P.K. Thomas, E.H. Lambert & R. Bunge, Eds. W.B. Saunders. Philadelphia . In press. 143 Alvord, E.C., Jr. 1968. The pathology of parkinsonism. In Pathology of the Nervous System. J. Minkler, Ed. 1: 1152– 1161. McGraw-Hill. New York . 144 Turner, B. 1968. Pathology of paralysis agitans. In Diseases of the Basal Ganglia. Handbook of Clinical Neurology. G.W. Bruyn & P.J. Vinken, Eds. 6: 212– 218. North-Holland Publishing. Amsterdam . 145 Whitehouse, P.J., J.C. Hedreen, C.L. White III & D.L. Price. Basal forebrain neurons in the dementia of Parkinson's disease. Citing Literature Volume396, Issue1Alzheimer's Disease, Down's Syndrome, and AgingOctober 1982Pages 145-164 ReferencesRelatedInformation