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The Effect of Testosterone on the Immune Response 1.-Mechanism of Action on Antibody-Forming Cells

1990; Taylor & Francis; Volume: 19; Issue: 3 Linguagem: Inglês

10.3109/08820139009041841

1532-4311

Sadi Ubaldo Rifé, Marı́a Gabriela Márquez, Alejandra Escalante, Teresa Velich,

Hormonal and reproductive studies

AbstractSex hormones are known to be Implicated in humoral and cellular immune responses. In this study we report the effects of orchidectomy and testosterone replacement on the immune response using T-dependent and T-independent antigens. It was found that the response was dependent on the nature of the antigen employed and on the presence of testosterone. The absence of testosterone receptors in spleen lymphocytes was also found. An hypothesis that testosterone regulates the immune system through the enhancement of suppressive activity is advanced.