Homozygosity at a class II MHC locus depresses female reproductive ability in European brown hares
2010; Wiley; Volume: 19; Issue: 19 Linguagem: Inglês
10.1111/j.1365-294x.2010.04765.x
ISSN1365-294X
AutoresSteve Smith, Thomas Mang, Joë̈lle Goü̈y de Bellocq, Helmut Schaschl, Claudia Zeitlhofer, Klaus Hackländer, Franz Suchentrunk,
Tópico(s)Sperm and Testicular Function
ResumoMolecular EcologyVolume 19, Issue 19 p. 4131-4143 Homozygosity at a class II MHC locus depresses female reproductive ability in European brown hares STEVE SMITH, STEVE SMITH Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, AustriaSearch for more papers by this authorTHOMAS MANG, THOMAS MANG Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, Austria Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UKSearch for more papers by this authorJOELLE GOÜY DE BELLOCQ, JOELLE GOÜY DE BELLOCQ Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, Austria Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, BelgiumSearch for more papers by this authorHELMUT SCHASCHL, HELMUT SCHASCHL Konrad Lorenz Institute for Ethology, Savoyenstr. 1A, 1160 Vienna, AustriaSearch for more papers by this authorCLAUDIA ZEITLHOFER, CLAUDIA ZEITLHOFER Institute of Wildlife Biology and Game Management, University of Natural Resources and Applied Life Sciences, Gregor-Mendel-Str. 33, 1180 Vienna, AustriaSearch for more papers by this authorKLAUS HACKLÄNDER, KLAUS HACKLÄNDER Institute of Wildlife Biology and Game Management, University of Natural Resources and Applied Life Sciences, Gregor-Mendel-Str. 33, 1180 Vienna, AustriaSearch for more papers by this authorFRANZ SUCHENTRUNK, FRANZ SUCHENTRUNK Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, AustriaSearch for more papers by this author STEVE SMITH, STEVE SMITH Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, AustriaSearch for more papers by this authorTHOMAS MANG, THOMAS MANG Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, Austria Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UKSearch for more papers by this authorJOELLE GOÜY DE BELLOCQ, JOELLE GOÜY DE BELLOCQ Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, Austria Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, BelgiumSearch for more papers by this authorHELMUT SCHASCHL, HELMUT SCHASCHL Konrad Lorenz Institute for Ethology, Savoyenstr. 1A, 1160 Vienna, AustriaSearch for more papers by this authorCLAUDIA ZEITLHOFER, CLAUDIA ZEITLHOFER Institute of Wildlife Biology and Game Management, University of Natural Resources and Applied Life Sciences, Gregor-Mendel-Str. 33, 1180 Vienna, AustriaSearch for more papers by this authorKLAUS HACKLÄNDER, KLAUS HACKLÄNDER Institute of Wildlife Biology and Game Management, University of Natural Resources and Applied Life Sciences, Gregor-Mendel-Str. 33, 1180 Vienna, AustriaSearch for more papers by this authorFRANZ SUCHENTRUNK, FRANZ SUCHENTRUNK Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Savoyenstr. 1, 1160 Vienna, AustriaSearch for more papers by this author First published: 20 August 2010 https://doi.org/10.1111/j.1365-294X.2010.04765.xCitations: 15 Steve Smith, Fax: +431 448 909 1537; E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The link between adaptive genetic variation, individual fitness and wildlife population dynamics is fundamental to the study of ecology and evolutionary biology. In this study, a Bayesian modelling approach was employed to examine whether individual variability at two major histocompatibility complex (MHC) class II loci (DQA and DRB) and eight neutral microsatellite loci explained variation in female reproductive success for wild populations of European brown hare (Lepus europaeus). We examined two aspects of reproduction: the ability to reproduce (sterility) and the number of offspring produced (fecundity). Samples were collected from eastern Austria, experiencing a sub-continental climatic regime, and from Belgium with a more Atlantic-influenced climate. As expected, reproductive success (both sterility and fecundity) was significantly influenced by age regardless of sampling locality. For Belgium, there was also a significant effect of DQA heterozygosity in determining whether females were able to reproduce (95% highest posterior density interval of the regression parameter [−3.64, −0.52]), but no corresponding effect was found for Austria. In neither region was reproduction significantly associated with heterozygosity at the DRB locus. DQA heterozygotes from both regions also showed a clear tendency, but not significantly so, to produce a larger number of offspring. Predictive simulations showed that, in Belgium, sub-populations of homozygotes will have higher rates of sterile individuals and lower average offspring numbers than heterozygotes. No similar effect is predicted for Austria. The mechanism for the spatial MHC effect is likely to be connected to mate choice for increased heterozygosity or to the linkage of certain MHC alleles with lethal recessives at other loci. Citing Literature Volume19, Issue19October 2010Pages 4131-4143 RelatedInformation
Referência(s)