Autologous peripheral blood stem cell transplantation for POEMS syndrome
2006; Lippincott Williams & Wilkins; Volume: 66; Issue: 1 Linguagem: Inglês
10.1212/01.wnl.0000188757.38495.23
ISSN1526-632X
AutoresSatoshi Kuwabara, Sonoko Misawa, Kazuaki Kanai, Yuriko Kikkawa, Masaharu Nishimura, Chiaki Nakaseko, R. K. Cho, Takamichi Hattori,
Tópico(s)Multiple Myeloma Research and Treatments
ResumoPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
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