An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers
2012; Wiley; Volume: 18; Issue: 22 Linguagem: Inglês
10.1002/chem.201200478
ISSN1521-3765
AutoresWangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong, Rui Wang,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoA rapid and efficient organocatalytic cascade sequence for the direct construction of spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the presence of a base. This process constitutes a powerful approach to the preparation of biologically important bispirooxindoles in high enantioselectivities (see scheme).
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