Synthesis of a 2‐arylsulphonylated tryptophan: the antibacterial activity of bovine lactoferricin peptides containing Trp(2‐Pmc)
2002; Wiley; Volume: 8; Issue: 7 Linguagem: Inglês
10.1002/psc.404
ISSN1099-1387
AutoresBengt Erik Haug, Jill Andersen, Øystein Rekdal, John S. Svendsen,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract A modified tryptophan, β‐[2‐(2,2,5,7,8‐pentamethylchroman‐6‐sulphonyl)‐indol‐3‐yl]alanine, Trp(2 − Pmc) = Tpc has been synthesized. Replacement of tryptophan in a bovine lactoferricin model peptide with the modified tryptophan resulted in peptides with a substantially increased antibacterial activity against Escherichia coli and Staphylococcus aureus . The most active peptides against each bacterial strain displayed minimal inhibitory concentrations of 7.5 μg/ml. Copyright © 2002 European Peptide Society and John Wiley & Sons, Ltd.
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