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Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children

2008; Wiley; Volume: 13; Issue: 7 Linguagem: Inglês

10.1111/j.1399-3046.2008.01068.x

1399-3046

Nobuhiro Nishio, Hiroshi Yagasaki, Yoshiyuki Takahashi, Asahito Hama, Hideki Muramatsu, Makito Tanaka, Nao Yoshida, Ayami Yoshimi, Kazuko Kudo, Masafumi Ito, Seiji Kojima,

Neutropenia and Cancer Infections

ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8-27 days) post-transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary infiltration (25%), and body weight gain (85%). On multivariate analysis, significant risk factors for ES included younger age (<8 yr old) and human leukocyte antigen disparity between donors and recipients. Univariate analysis showed that patients with ES had a higher incidence of developing chronic graft-versus-host disease and ES was not associated with other complications. Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases.