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Structure Elucidation of Sch 725674 from Aspergillus sp.

2005; Springer Nature; Volume: 58; Issue: 8 Linguagem: Inglês

10.1038/ja.2005.74

1881-1469

Shu‐Wei Yang, Tze‐Ming Chan, Joseph Terracciano, David Loebenberg, Mahesh Patel, Min Chu,

Synthetic Organic Chemistry Methods

A new macrolide Sch725674 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was accomplished based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 32 microg/ml, respectively.