Direct inhibitors of InhA are active against Mycobacterium tuberculosis
2015; American Association for the Advancement of Science; Volume: 7; Issue: 269 Linguagem: Inglês
10.1126/scitranslmed.3010597
ISSN1946-6242
AutoresUjjini H. Manjunatha, Srinivasa P. S. Rao, Ravinder Reddy Kondreddi, Christian G. Noble, Luis R. Camacho, Bee Huat Tan, Seow Hwee Ng, Pearly Shuyi Ng, Leong L. Ng, Suresh B. Lakshminarayana, Maxime Hervé, Susan Barnes, Weixuan Yu, Kelli Kuhen, Francesca Blasco, David Beer, John R. Walker, Peter J. Tonge, Richard Glynne, Paul W. Smith, Thierry T. Diagana,
Tópico(s)Cancer therapeutics and mechanisms
Resumo4-Hydroxy-2-pyridones, direct inhibitors of the mycobacterial protein InhA, are active against multidrug-resistant Mycobacterium tuberculosis .
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