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Intensive versus Conventional Glucose Control in Critically Ill Patients

2009; Massachusetts Medical Society; Volume: 360; Issue: 13 Linguagem: Inglês

10.1056/nejmoa0810625

1533-4406

Nice-Sugar Study Investigators, Dean R. Chittock, Sheng‐Chiang Su, D. G. Blair, David R. Foster, Rinaldo Bellomo, Richard J. Cook, V. Dhingra, Peter Dodek, Paul D. N. Hebert, William R. Henderson, Stéphane Héritier, D. Heyland, Colin McArthur, Ellen McDonald, Imogen Mitchell, Richard J. Norton, J. Potter, Bruce Robinson, Juan J. Ronco,

Metabolism, Diabetes, and Cancer

Within 24 hours after admission to an intensive care unit (ICU), adults who were expected to require treatment in the ICU on 3 or more consecutive days were randomly assigned to undergo either intensive glucose control, with a target blood glucose range of 81 to 108 mg per deciliter (4.5 to 6.0 mmol per liter), or conventional glucose control, with a target of 180 mg or less per deciliter (10.0 mmol or less per liter). We defined the primary end point as death from any cause within 90 days after randomization.