HYPERBARIC OXYGEN THERAPY FOR RADIATION INDUCED HEMORRHAGIC CYSTITIS
1999; Lippincott Williams & Wilkins; Volume: 161; Issue: 2 Linguagem: Inglês
10.1016/s0022-5347(01)61914-1
ISSN1527-3792
AutoresRanjiv Mathews, NATARAJAN RAJAN, LAURA JOSEFSON, Enrico Camporesi, Zahi N. Makhuli,
Tópico(s)Cancer and Skin Lesions
ResumoNo AccessJournal of UrologyClinical Urology: Original Articles1 Feb 1999HYPERBARIC OXYGEN THERAPY FOR RADIATION INDUCED HEMORRHAGIC CYSTITIS RANJIV MATHEWS, NATARAJAN RAJAN, LAURA JOSEFSON, ENRICO CAMPORESI, and ZAHI MAKHULI RANJIV MATHEWSRANJIV MATHEWS More articles by this author , NATARAJAN RAJANNATARAJAN RAJAN More articles by this author , LAURA JOSEFSONLAURA JOSEFSON More articles by this author , ENRICO CAMPORESIENRICO CAMPORESI More articles by this author , and ZAHI MAKHULIZAHI MAKHULI More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61914-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Radiation therapy has been used successfully to treat pelvic malignancy but morbidity from hemorrhagic cystitis remains a major long-term sequela in 1 to 2% of patients. Obliterative endarteritis secondary to ionizing radiation leads to tissue hypoxia and poor healing. Hyperbaric oxygen therapy has been demonstrated to improve angiogenesis and promote healing in radiation injured tissue, including the bladder. We describe the treatment and long-term followup of a cohort of patients treated with hyperbaric oxygen for hemorrhagic cystitis. Materials and Methods: A total of 17 patients (mean age 62 years) with hemorrhagic cystitis received hyperbaric oxygen following failure of standard treatment modalities. Hyperbaric oxygen was administered on a once daily schedule (mean number of treatments 14) until hematuria resolved. Followup ranged from 9 to 60 months (mean 21). Results: Hematuria resolved completely in 11 of 17 patients (64%), 2 had only residual microscopic hematuria, 2 had improvement but died of complications relating to cancer shortly after completion of treatment and 2 had recurrence of gross hematuria. Early application of hyperbaric oxygen was associated with earlier resolution of hemorrhagic cystitis. Conclusions: Radiation induced hemorrhagic cystitis that does not respond to standard regimens can be successfully treated with hyperbaric oxygen. This modality is well tolerated even in patients debilitated by advanced cancer and blood loss. Long-term remission can be achieved in the majority of patients. References 1 : Morbidity of pelvic lymphadenectomy, radical retropubic prostatectomy and external radiotherapy in patients with localized prostate cancer. Scand. J. Urol. Nephrol.1994; 28: 265. Google Scholar 2 : Long-term follow-up of patients treated by radiation therapy of clinically localized prostate cancer. Canad. J. Oncol.1994; 1: 31. Google Scholar 3 : Outcomes of radiotherapy and combined modality treatment of cervical cancer in patients under 35. Eur. J. Gynec. Oncol.1996; 17: 400. Google Scholar 4 : Abdominoperineal resection combined with pre- and postoperative radiation therapy in the treatment of low-lying rectal carcinoma. Int. J. Rad. Oncol. Biol. Phys.1997; 37: 59. Google Scholar 5 : Visceral complications of supervoltage radiotherapy for carcinoma of the bladder. Brit. J. Surg.1970; 57: 409. Google Scholar 6 : Effect of pelvic radiotherapy for prostate cancer on bowel, bladder and sexual function: the patient's perspective. Urology1996; 47: 387. Google Scholar 7 : Sequelae of definitive radiation therapy for prostate cancer localized to the pelvis. Urology1992; 44: 876. Google Scholar 8 : Pelvic radiation necrosis and radiation cystitis. In: Hyperbaric Medicine Practice. Edited by . Arizona: Best Publishing Co.1994: 505. chapt. 24. Google Scholar 9 : Hemorrhagic cystitis. AUA Update Series1992; vol. 11: 242. lesson 31. Google Scholar 10 : Treatment of radiation or cyclosphosphamide induced hemorrhagic cystitis using conjugated estrogen. J. Urol.1990; 144: 41. Abstract, Google Scholar 11 : Intravesical formalin for hemorrhagic cystitis following irradiation of cancer of the cervix. Int. J. Gynec. Obst.1993; 42: 131. Google Scholar 12 : Hyperbaric oxygen therapy for wound complications after surgery in the irradiated head and neck: a review of the literature and report of 15 consecutive patients. Head Neck1997; 19: 315. Google Scholar 13 : Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns: a review. Burns1994; 20: 5. Google Scholar 14 : Hyperbaric oxygen therapy in plastic surgery: a review article. Plast. and Reconstr. Surg.1991; 88: 898. Google Scholar 15 : Cutaneous ureterostomy as last resort of intractable hemorrhagic cystitis following radiation. Brit. J. Urol.1983; 55: 392. Google Scholar 16 : Primary treatment of radiation-induced hemorrhagic cystitis with hyperbaric oxygen: 10-year experience. J. Urol.1994; 151: 1514. Link, Google Scholar 17 : Hyperbaric oxygen treatment for experimental cyclosphosphamide-induced hemorrhagic cystitis. J. Urol.1993; 149: 1617. Abstract, Google Scholar 18 : Treatment of radiation-induced cystitis with hyperbaric oxygen. J. Urol.1985; 134: 352. Link, Google Scholar 19 : Hyperbaric oxygen treatment: 10 years’ experience of a Regional Infectious Diseases Unit. J. Infect.1983; 6: 17. Google Scholar 20 : Hyperbaric oxygen treatment for hemorrhagic radiation cystitis. Lancet1995; 346: 803. Google Scholar 21 : Hyperbaric oxygen: primary treatment of radiation-induced hemorrhagic cystitis. J. Urol.1989; 142: 43. Link, Google Scholar 22 : Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis. J. Urol.1993; 150: 332. Link, Google Scholar 23 : Hyperbaric oxygen therapy. J.A.M.A.1990; 263: 2216. Google Scholar From the Departments of Urology and Anesthesiology, State University of New York Health Science Center, Syracuse, New YorkPresented at annual meeting of American Urological Association, New Orleans, Louisiana, April 12-17, 1997.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byCORMAN J, McCLURE D, PRITCHETT R, KOZLOWSKI P and HAMPSON N (2018) Treatment of Radiation Induced Hemorrhagic Cystitis With Hyperbaric Oxygen.Journal of Urology, VOL. 169, NO. 6, (2200-2202), Online publication date: 1-Jun-2003.KORKMAZ A, OTER S, DEVECİ S, GOKSOY C and BİLGİC H (2018) PREVENTION OF FURTHER CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS BY HYPERBARIC OXYGEN AND MESNA IN GUINEA PIGSJournal of Urology, VOL. 166, NO. 3, (1119-1123), Online publication date: 1-Sep-2001.GONZALEZ C, CASE J and NADLER R (2018) GLUTARALDEHYDE CROSS-LINKED COLLAGEN OCCLUSION OF THE URETERAL ORIFICES WITH PERCUTANEOUS NEPHROSTOMY: A MINIMALLY INVASIVE OPTION FOR TREATMENT REFRACTORY HEMORRHAGIC CYSTITISJournal of Urology, VOL. 166, NO. 3, (977-978), Online publication date: 1-Sep-2001. Volume 161Issue 2February 1999Page: 435-437 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information RANJIV MATHEWS More articles by this author NATARAJAN RAJAN More articles by this author LAURA JOSEFSON More articles by this author ENRICO CAMPORESI More articles by this author ZAHI MAKHULI More articles by this author Expand All Advertisement PDF downloadLoading ...
Referência(s)