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Autosis is a Na + ,K + -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

2013; National Academy of Sciences; Volume: 110; Issue: 51 Linguagem: Inglês

10.1073/pnas.1319661110

1091-6490

Yang Liu, Sanae Shoji-Kawata, Rhea Sumpter, Yongjie Wei, Vanessa Ginet, Liying Zhang, Bruce A. Posner, Khoa Tran, Douglas R. Green, Ramnik J. Xavier, Stanley Y. Shaw, Robert Clarke, Julien Puyal, Beth Levine,

Advanced Glycation End Products research

Significance We show that the selective overactivation of autophagy can cause cell death with unique morphological features distinct from apoptosis or necrosis. This unique type of autophagic cell death, termed “autosis,” occurs not only in vitro but also in vivo in cerebral hypoxia–ischemia. Moreover, autosis is inhibited both in vitro and in vivo by cardiac glycosides, which are Na + ,K + -ATPase antagonists used in clinical medicine. Our findings contribute to the basic understanding of cell-death mechanisms and suggest strategies for protecting cells against stresses such as hypoxia–ischemia.