Delivering Drugs to the Central Nervous System: A Medicinal Chemistry or a Pharmaceutical Technology Issue?
2006; Bentham Science Publishers; Volume: 13; Issue: 15 Linguagem: Inglês
10.2174/092986706777452461
ISSN1875-533X
AutoresMaurizio Ricci, Paolo Blasi, Stefano Giovagnoli, Carlo Riccardo Rossi,
Tópico(s)Chemical Reactions and Isotopes
ResumoThis review aims to summarize the non-invasive approaches employed in delivering drugs to the central nervous system which is severely hindered by the presence of the blood-brain barrier (BBB) that limits molecular permeation. Particular attention will be placed on the several available strategies for delivering drugs into the brain, through circumvention of the BBB, in order to critically address the medicinal chemistry and the pharmaceutical technology contributions. Keywords: Blood-brain barrier, brain targeting, chemical delivery systems, CNS delivery, SLN, pro-drugs, liposomes, polymeric nanoparticles
Referência(s)