Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin
2006; American Chemical Society; Volume: 8; Issue: 22 Linguagem: Inglês
10.1021/ol060946z
ISSN1523-7060
AutoresDiana Samaroo, Clifford E. Soll, L. Todaro, Charles Michael Drain,
Tópico(s)Fluorine in Organic Chemistry
ResumoWe report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF20) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the para-fluorine groups in TPPF20 by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF20 is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications.
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