Genetic and biological characterization of human myeloma cell lines: An overwiew of the lines established at Kawasaki Medical School
2000; Wiley; Volume: 1; Issue: 1 Linguagem: Inglês
10.1002/1438-826x(200005)1
ISSN1438-826X
AutoresTakemi Otsuki, Osamu Yamada, Kenichiro Yata, Naozo Nakazawa, Masafumi Taniwaki, Haruko Sakaguchi, Yoshihito Yawata, Ayako Ueki,
Tópico(s)Multiple Myeloma Research and Treatments
ResumoGene Function & DiseaseVolume 1, Issue 1 p. 48-56 Gene Structure and Function Genetic and biological characterization of human myeloma cell lines: An overwiew of the lines established at Kawasaki Medical School Takemi Otsuki, Corresponding Author Takemi Otsuki [email protected] Department of Hygiene, Kawasaki Medical School, Okayama, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan. Phone: +81-86-462-1111; Fax: +81-86-462-1199;Search for more papers by this authorOsamu Yamada, Osamu Yamada Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorKenichiro Yata, Kenichiro Yata Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorNaozo Nakazawa, Naozo Nakazawa Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorMasafumi Taniwaki, Masafumi Taniwaki Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorHaruko Sakaguchi, Haruko Sakaguchi Department of Hygiene, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorYoshihito Yawata, Yoshihito Yawata Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorAyako Ueki, Ayako Ueki Department of Hygiene, Kawasaki Medical School, Okayama, JapanSearch for more papers by this author Takemi Otsuki, Corresponding Author Takemi Otsuki [email protected] Department of Hygiene, Kawasaki Medical School, Okayama, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan. Phone: +81-86-462-1111; Fax: +81-86-462-1199;Search for more papers by this authorOsamu Yamada, Osamu Yamada Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorKenichiro Yata, Kenichiro Yata Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorNaozo Nakazawa, Naozo Nakazawa Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorMasafumi Taniwaki, Masafumi Taniwaki Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorHaruko Sakaguchi, Haruko Sakaguchi Department of Hygiene, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorYoshihito Yawata, Yoshihito Yawata Division of Hematology, Department of Internal Medicine, Kawasaki Medical School, Okayama, JapanSearch for more papers by this authorAyako Ueki, Ayako Ueki Department of Hygiene, Kawasaki Medical School, Okayama, JapanSearch for more papers by this author First published: 15 May 2000 https://doi.org/10.1002/1438-826X(200005)1:1 3.0.CO;2-BCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Human myeloma cell lines are useful as an in vitro model for the genetic and cellular biological characterization of primary myeloma cells. We have been attempting to establish myeloma lines since 1979 for the study of the cytogenetic, molecular and cellular biological aspects of myeloma cells and to resolve the clinical problems associated with multiple myeloma. The establishment and characterization of some of these lines have been reported. Here we review the lines established at Kawasaki Medical School and discuss investigations related to the clinical manifestation of myeloma using these lines. For instance, the relation between myeloma specific chromosomal translocations, such as t(11;14)(q13;q32), t(8;14)(q24;q32), and t(4;14)(q16.3;q32.3), found in some of the cell lines and gene expression was examined. References [1] Matsuoka, U., Moore, G.E., Yagi, Y., Pressman, D. 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