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Cohort profile: Risk evaluation of cancers in C hinese diabetic individuals: a longitudinal ( REACTION ) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)

2013; Wiley; Volume: 6; Issue: 2 Linguagem: Inglês

10.1111/1753-0407.12108

1753-0393

Yufang Bi, Jieli Lu, Weiqing Wang, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Qin Wan, Shengli Wu, Tao Yang, Li Yan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao, Qing Su, Zhen Ye, Youming Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Jie Zhang, Jichao Sun, Meng Dai, Min Xu, Yu Xu, Yuhong Chen, Shenghan Lai, Zachary T. Bloomgarden, Donghui Li, Guang Ning,

Diabetes, Cardiovascular Risks, and Lipoproteins

Abstract Objective To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the C hinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods Between 2011 and 2012, 259 657 community‐dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland C hina to participant in the baseline survey of the REACTION study, with follow‐up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio‐samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results The mean ± standard deviation ( SD ) age of this cohort was 57 ± 10 years. And the prevalence of pre‐existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio ( PR ) of stomach cancer ( PR : 0.38, 95% CI : 0.16–0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites ( PR : 1.36, 95% CI : 1.20–1.56), and cancer of the breast ( PR : 1.56, 95% CI : 1.21–2.00), the endometrium ( PR : 1.58, 95% CI : 1.16–2.15), and the thyroid ( PR : 1.53, 95% CI : 1.03–2.27). Conclusion The multi‐center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259 657 adults from the general population across the C hina.