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Luteinizing hormone supplementation increases pregnancy rates in gonadotropin-releasing hormone antagonist donor cycles

2004; Elsevier BV; Volume: 82; Issue: 2 Linguagem: Inglês

10.1016/j.fertnstert.2004.03.020

1556-5653

Belen Acevedo, Marta García Sánchez, José L. Gómez, Jorge Cuadros, Elisabetta Ricciarelli, Eleuterio R. Hernández,

Assisted Reproductive Technology and Twin Pregnancy

Abstract Objective To determine whether LH supplementation improved pregnancy and implantation rates in GnRH antagonist donor cycles. Design Donors were randomly assigned to a protocol using GnRH antagonist (GnRH-a) alone or GnRH-a + recombinant LH. Analysis of variance, Student's t -test and Fisher's exact test were used where appropriate . Setting Private clinical setting. Patient(s) Young voluntary donors with antagonist (n = 20) and antagonist + LH (n = 22). Fifty-five patients received oocytes. Intervention(s) Donors received the GnRH-a (Cetrorelix, 0.25 mg/day) alone or in combination with recombinant LH (75 IU/day). Ovulation induction was carried out with recombinant FSH in a step-down protocol. The endometrial tissue of recipient patients was prepared with oral E 2 and P. Main outcome measure(s) Pregnancy and implantation rates in a donor program. Result(s) A significant increase in MII oocyte (80% vs. 71%), fertilization rates (83% vs. 71%), G1 embryos (17% vs. 3%), and implantation rates (35% vs. 15%), were found in recipients whose embryos originated from donors receiving GnRH-a + recombinant LH as compared to donors receiving GnRH-a alone. Estradiol levels, pregnancy/transfer and clinical pregnancies were lower (not significant) in donors treated with the GnRH-a alone vs. those receiving the recombinant LH-supplemented GnRH-a. Conclusion(s) The LH supplementation improved the possibilities of gestation for recipients whose embryos originated from GnRH-a-treated donors.