Conditioned Taste Aversion in Rats following Intrathecal Administration of Contrast Media
1996; SAGE Publishing; Volume: 37; Issue: 1P1 Linguagem: Inglês
10.1177/02841851960371p122
ISSN1600-0455
AutoresAnna La Noce, Aljoša Danieli, Francesco Bertani, Piero Tirone, Christoph de Haën,
Tópico(s)Traumatic Brain Injury and Neurovascular Disturbances
ResumoPurpose: The occurrence of side-effects such as visceral malaise after intrathecal administration of the non-ionic radiography contrast media iomeprol, iopamidol, and iotrolan was assessed in rats by the conditioned taste aversion procedure. Methods: Reduced preference towards a saccharose solution compared with normal water following intraventricular administration of a contrast medium was used as a measure of the aversive response. Results: At a dose of 100 mg I/kg none of the tested contrast media induced aversion. At 200 and 300 mg I/kg, both iopamidol and iomeprol induced significant aversive responses with respect to control, although the response of the iomeprol group appeared milder than that of the iopamidol group at a dose of 200 mg I/kg. Iotrolan could be tested only at the lowest dose since the high doses caused excessive mortality. Conclusion: Intrathecally administered iomeprol appeared to be well tolerated in rats at doses higher than those suggested for clinical use.
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