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Sorbitol dehydrogenase genetics in the mouse: A ‘;null’ mutant in a ‘;European’ C57BL strain

1982; Volume: 13; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2052.1982.tb01569.x

2053-3179

Roger S. Holmes, John A. Duley, J. Hilgers,

Aldose Reductase and Taurine

Summary A ‘;null’ activity variant phenotype for sorbitol dehydrogenase (SDH) was observed in C57BL/LiA mice and used to examine the genetics of this enzyme. Linkage studies of the locus ( Sdh‐1 ) with non‐agouti (a) and a biochemical Iocus encoding liver L‐α‐hydroxyacid oxidase ( Hao‐1 ) demonstrated that it is coincident with or closely linked to the structural locus, previously localized on chromosome 2. Alcohol dehydrogenase (ADH) isozymes were also examined, since the liver A 2 isozyme exhibited some activity as a sorbitol dehydrogenase on cellulose acetate zymograms. It is apparent that SDH activity is not ‘;essential’ in this mouse strain.