Revisão Acesso aberto Revisado por pares

The genetics of asthma and atopy

1995; Wiley; Volume: 50; Issue: 11 Linguagem: Inglês

10.1111/j.1398-9995.1995.tb02491.x

ISSN

1398-9995

Autores

Carolien Panhuysen, Deborah A. Meyers, D.S. Postma, ER Bleecker,

Tópico(s)

Cystic Fibrosis Research Advances

Resumo

AllergyVolume 50, Issue 11 p. 863-869 Free Access The genetics of asthma and atopy C. I. M. Panhuysen, C. I. M. Panhuysen University of Maryland at Baltimore, MD, USASearch for more papers by this authorD. A. Meyers, D. A. Meyers Johns Hopkins University, Baltimore, MD, USASearch for more papers by this authorD. S. Postma, D. S. Postma University Hospital, Groningen, The NetherlandsSearch for more papers by this authorE. R. Bleecker, Corresponding Author E. R. Bleecker University of Maryland at Baltimore, MD, USAE. R. Bleecker, MD, University of Maryland School of Medicine 10 S. Pine Street, Suite 800 Baltimore, MD 21201 USASearch for more papers by this author C. I. M. Panhuysen, C. I. M. Panhuysen University of Maryland at Baltimore, MD, USASearch for more papers by this authorD. A. Meyers, D. A. Meyers Johns Hopkins University, Baltimore, MD, USASearch for more papers by this authorD. S. Postma, D. S. Postma University Hospital, Groningen, The NetherlandsSearch for more papers by this authorE. R. Bleecker, Corresponding Author E. R. Bleecker University of Maryland at Baltimore, MD, USAE. R. Bleecker, MD, University of Maryland School of Medicine 10 S. Pine Street, Suite 800 Baltimore, MD 21201 USASearch for more papers by this author First published: November 1995 https://doi.org/10.1111/j.1398-9995.1995.tb02491.xCitations: 26AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Holgate ST, Beasley R, Twentyman OP. The pathogenesis and significance of bronchial hyperresponsiveness in airway disease. Clin Sci 1987: 73: 561–72. 2 Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991: 325: 1067–71. 3 Gergen PJ, Weiss KB. The increasing problem of asthma in the United States. Am Rev Respir Dis 1992: 146: 823–4. 4 Peat JK, van den Berg RH, Green WF, Mellis CM, Leeder SR, Woolcock AJ. Changing prevalence of asthma in Australian children. BMJ 1994: 308: 1591–6. 5 Ninan TK, Russel G. Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ 1992: 304: 873–5. 6 Burr ML. Epidemiology of clinical allergy. Monogr Allergy 1993: 31: 1–8. 7 Hopp RJ, Bewtra AK, Biven R, Nair NM, Townley RG. Bronchial reactivity pattern in nonasthmatic parents of asthmatics. Ann Allergy 1988: 61: 184–6. 8 Sibbald B, Turner-Warwick M. Factors influencing the prevalence of asthma among first degree relatives of extrinsic and intrinsic asthmatics. Thorax 1979: 34: 332–7. 9 Sibbald B, Horn MEC, Brain EA, Gregg I. Genetic factors in childhood asthma. Thorax 1980: 35: 671–4. 10 Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990: 46: 222–8. 11 Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990: 46: 229–41. 12 Meyers DA, Postma DS, Panhuysen CIM, Amelung PJ, Levitt RC, Bleecker ER. Genetics of asthma and COPD. V. Bronchitis. DS Postma, J Gerritsen, eds. Assen , The Netherlands : Van Gorcum, 1994. 13 Ott J. Analysis of human genetics. Revised ed. Baltimore , MD : Johns Hopkins University Press, 1991. 14 Morton NE. Sequential tests for the detection of linkage. Am J Hum Genet 1955: 7: 277–318. 15 Dracapoli NC, Haines JL, Korf BR, et al. Genetic mapping. In: Current protocols in human genetics. John Wiley, 1994. 16 Bye MR, Ewing JM, Quittell LM. Cystic fibrosis. Lung 1994: 172: 251–70. 17 Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD. Relationship of bronchial responsiveness assessed by methacholine to serum IgE, lung function, symptoms, and diagnosis in 11-year-old New Zealand children. J Allergy Clin Immunol 1992: 90: 376–85. 18 Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD. Relationship of bronchial responsiveness to allergy skin-test reactivity, lung function, respiratory symptoms, and diagnosis in 13-year-old New Zealand children. J Allergy Clin Immunol 1995: 95: 548–56. 19 Ciba Guest Symposium. Terminology, definitions, and classification of chronic pulmonary emphysema and related conditions. Thorax 1959: 14: 286–99. 20 American Thoracic Society. Definitions and classification of chronic bronchitis, asthma, and pulmonary emphysema. Am Rev Respir Dis 1962: 85: 762–8. 21 Medical Research Council. Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet 1965: i: 775–9. 22 Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989: 320: 271–7. 23 Lebowitz MD, Barbee R, Burrows B. Family concordance of IgE, atopy, and disease. J Allergy Clin Immunol 1984: 73: 259. 24 Duffy DL, Martin NG, Battistuta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 1990: 142: 1351–8. 25 Edfors-Lubs M. Allergy in 7000 twin pairs. Acta Allergol 1971: 26: 249–85. 26 Hopp RJ, Bewtra AK, Watt GD, Nair NM, Townley RG. Genetic analysis of allergic disease in twins. J Allergy Clin Immunol 1984: 73: 265–70. 27 Hopp RJ, Townley RG, Biven R, Bewtra AK, Nair NM. The presence of airway reactivity before the development of asthma. Am Rev Respir Dis 1990: 141: 2–8. 28 Tashkin DP, Altose MD, Bleecker ER, et al. The Lung Health Study 3. The Lung Health Study: airway responsiveness to inhaled methacholine in smokers with mild to moderate airflow limitation. Am Rev Respir Dis 1992: 145: 301–10. 29 O'Connor GT, Sparrow D, Weiss ST. The role of allergy and nonspecific airway hyperresponsiveness in the pathogenesis of chronic obstructive pulmonary disease. State of the Art. Am Rev Respir Dis 1989: 140: 225–52. 30 Roorda RJ, Gerritsen J, van Aalderen WMC, et al. Follow-up of asthma from childhood to adulthood: influence of potential childhood risk factors on the outcome of pulmonary function and bronchial responsiveness in adulthood. J Allergy Clin Immunol 1994: 93(3): 575–84. 31 Boushy HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperresponsiveness. Am Rev Respir Dis 1980: 121: 389–413. 32 Postma DS, De Vries, K, Koeter GH, Sluiter HJ. Independent influence of reversibility of air-flow obstruction and non-specific hyperreactivity on the long-term course of lung function in chronic air-flow obstruction. Am Rev Respir Dis 1986: 134: 276–80. 33 Schwartz J, Gold D, Dockery DW, Weiss ST, Speizer FE. Predictors of asthma and persistent wheeze in a national sample of children in the United States. Am Rev Respir Dis 1990: 142: 555–62. 34 Burr ML, Miskelly FG, Butland BK, Merrett TG, Vaughan-Williams E. Environmental factors and symptoms in infants at high risk of allergy. J Epidemiol Commun Health 1989: 43: 125–32. 35 Arshad SH, Hide DW. Effect of environmental factors on the development of allergic disorders in infancy. J Allergy Clin Immunol 1992: 90: 235–41. 36 Longo G, Strinati R, Poli F, Fumi F. Genetic factors in nonspecific bronchial hyperreactivity. An epidemiologic study. Am J Dis Child 1987: 141: 331–4. 37 Cookson Wocm, Hopkin, JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989: i: 1292–5. 38 Hopkin JM, Cookson Wocm, Young, RP. Asthma, atopy and genetic linkage. Ann N Y Acad Sci 1991: 629: 26–30. 39 Moffatt MF, Sharp PA, Faux JA, Young RP, Cookson Wocm, Hopkin, JM. Factors confounding genetic linkage between atopy and chromosome 11q. Clin Exp Allergy 1992: 22: 1046–51. 40 Cookson Wocm, Young, RP, Sandford AJ, et al. Maternal inheritance of IgE responsiveness on chromosome 11q. Lancet 1992: 340: 381–4. 41 Hizawa N, Yamaguchi E, Ohe M, et al. Lack of linkage between atopy and locus 11q13. Clin Exp Allergy 1992: 22: 1065–9. 42 Rich SS, Roitman-Johnson B, Greenberg B, Roberts S, Blumenthal MN. Genetic evidence of atopy in three large kindreds. No evidence of linkage to D11S97. Clin Exp Allergy 1992: 22: 1070–6. 43 Lympany P, Welch K, MacCochrane G, Kemeny DM, Lee TH. Genetic analysis using DNA polymorphism of the linkage between chromosome 11ql3 and atopy and BHR to methacholine. J Allergy Clin Immunol 1992: 89: 619–28. 44 Lympany P, Welch K, Cochrane GM, Kemeny DM, Lee TH. Genetic analysis of the linkage between chromosome llq13 and atopy. Clin Exp Allergy 1992: 22: 1085–92. 45 Amelung PJ, Panhuysen CIM, Postma DS, et al. Atopy and bronchial hyperresponsiveness. Exclusion of linkage to markers on chromosome 11q and 6p. Clin Exp Allergy 1992: 22: 1077–84. 46 Brereton HM, Ruffinb RE, Thompson PJ, Turner DR. Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptor. Clin Exp Allergy 1994: 24: 868–77. 47 Bruderman I, Cohen R, Shachor J, Horowitz I. Bronchial response to methacholine in parents of asthmatic children. Chest 1987: 91(2): 210–13. 48 Townley RG, Bewtra MD, Wilson AF, et al. Segregation analysis of bronchial response to methacholine inhalation in families with and without asthma. J Allergy Clin Immunol 1986: 77: 101–7. 49 Gerrard JW, Horne S, Vickers P, et al. Serum IgE levels in parents and children. J Pediatr 1974: 85: 660–5. 50 Meyers DA, Beaty WB, Freidhoff LR, Marsh DG. Inheritance of serum IgE (basal levels) in man. Am J Hum Genet 1987: 41(1): 51–62. 51 Gerrard JW, Rao DC, Morton NE. A genetic study of immunoglobulin E. Am J Hum Genet 1978: 30: 46–58. 52 Meyers DA, Beaty TH, Colyer CR, Marsh DG. Genetics of total serum IgE levels: a regressive model approach to segregation analysis. Genet Epidemiol 1991: 8: 351–9. 53 Meyers DA, Postma DS, Panhuysen CIM, et al. Evidence for a locus regulating total serum IgE level mapping to chromosome 5. Genomics 1994: 23: 464–70. 54 Dizier MH, Hill M, James A, et al. Detection of a recessive major gene for high IgE levels acting independently of specific response to allergens. Genet Epidemiol 1995: 12: 93–105. 55 Martinez FD, Holberg CJ, Halonen M, Morgan WJ, Wright AL, Taussig LM. Evidence for mendelian inheritance of serum IgE levels in Hispanic and non-Hispanic white families. Am J Hum Genet 1994: 55(3): 555–65. 56 Sandford AJ, Shirakawa T, Moffatt MF, et al. Localisation of atopy and β subunit of high-affinity IgE receptor (Fe epsilon RI) on chromosome 11q. Lancet 1993: 341: 332–4. 57 Shirakawa T, Li A, Dubowitz M, et al. Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nature Genet 1994: 7: 125–30. 58 Marsh DG, Neely JD, Breazeale DR, et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994: 264: 1152–6. 59 Xu J, Levitt RC, Panhuysen CMI, et al. Evidence for two unlinked loci regulating total serum IgE levels. Am J Hum Genet 1995: 57: 425–30. 60 Postma DS, Bleecker ER, Amelung PJ, et al. Genetic susceptibility to asthma: bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995: 333: 894–900. 61 Reishaus E, Innis M, Macintyre N, Liggett SB. Mutations in the gene encoding for the β2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993: 8: 334–9. 62 Moffatt MF, Hill MR, Cornelis F, et al. Genetic linkage of T-cell receptor α/δ complex to specific IgE responses. Lancet 1994: 343: 1597–1600. Citing Literature Volume50, Issue11November 1995Pages 863-869 ReferencesRelatedInformation

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