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Association of HLA‐DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects

1988; Wiley; Volume: 31; Issue: 4 Linguagem: Inglês

10.1111/j.1399-0039.1988.tb02083.x

1399-0039

Linda R. Freidhoff, Eva Ehrlich-Kautzky, Deborah A. Meyers, Aftab A. Ansari, Wilma Β. Bias, David G. Marsh,

Dermatology and Skin Diseases

Associations between HLA type and IgE or IgG antibody (Ab) responses to two well‐characterized, antigenetically non‐crossreactive components of Lolium perenne (rye grass) pollen extract, Lot p I (Rye I) and Lolp II (Rye II) were studied in two groups of skin‐test positive (ST+) Caucasoid adults. By both nonparametric and parametric statistical methods, significant associations were found between Ab responses to both Lol I arid Lol II and the possession of HLA‐DR3. In view of the well‐known associations of both DR3 and B8 (which are in linkage disequilibrium) with many autoimmune diseases, differences in anti‐ Lol I and anti‐ Lol II mean log[Ab] levels between B8+, DR3‐vs B8‐, DR3‐subjects and B8+, DR3+ vs B8‐, DR3+ subjects were investigated. No differences were found. Our data, along with recent RFLP and DNA sequence studies, suggest that an Ia molecule involved in immune recognition of a similar major Ia recognition site of both the Lol molecules may consist of a DR3α‐β, pair.