Portal de Periódicos da CAPES

Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells

2014; Frontiers Media; Volume: 5; Linguagem: Inglês

10.3389/fimmu.2014.00092

1664-3224

Ana M. Avalos, Hidde L. Ploegh,

Immune Cell Function and Interaction

B cells are efficient antigen presenting cells (APCs) by means of antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review we describe the steps required for antigen uptake, processing and loading onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.