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Vitamin D 3 and psoriasis: A randomized double-blind placebo-controlled study

1990; Informa; Volume: 1; Issue: 5 Linguagem: Inglês

10.3109/09546639009086743

1471-1753

Maqsood A. Siddiqui, M. M. Al-Khawajah,

Dermatology and Skin Diseases

A few open studies on small groups of patients have reported the efficacy of oral vitamin D3 in the treatment of psoriasis. To further characterize the therapeutic potential of this agent a placebo-controlled double-blind study was undertaken on a larger group of patients. Vitamin D3 (the active 1-α-hydroxy form) 1 μg/day and a placebo in a similar presentation were given in coded vials to 50 patients. Slight improvement was observed in 9 (45%) patients receiving vitamin D3 and 8 (38%) patients receiving placebo showed similar improvement, indicating that this regimen is not effective in the treatment of moderate to severe psoriasis.