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The Danger Model: A Renewed Sense of Self

2002; American Association for the Advancement of Science; Volume: 296; Issue: 5566 Linguagem: Inglês

10.1126/science.1071059

1095-9203

Polly Matzinger,

Viral Infections and Outbreaks Research

For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.