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Conservative Surgical Therapy for Leydig Cell Tumor

2007; Lippincott Williams & Wilkins; Volume: 178; Issue: 2 Linguagem: Inglês

10.1016/j.juro.2007.03.108

1527-3792

Luca Carmignani, Renzo Colombo, Franco Gadda, Giacomo Galasso, Andrea Lania, Juan Palou, Ferrán Algaba, Humberto Villavicencio, Giovanni M. Colpi, Ottavio De Cobelli, Roberto Salvioni, Giorgio Pizzocaro, Patrizio Rigatti, Francesco Rocco,

Sexual Differentiation and Disorders

No AccessJournal of UrologyAdult urology1 Aug 2007Conservative Surgical Therapy for Leydig Cell Tumor Luca Carmignani, Renzo Colombo, Franco Gadda, Giacomo Galasso, Andrea Lania, Juan Palou, Ferran Algaba, Humberto Villavicencio, Giovanni Maria Colpi, Ottavio Decobelli, Roberto Salvioni, Giorgio Pizzocaro, Patrizio Rigatti, and Francesco Rocco Luca CarmignaniLuca Carmignani Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy , Renzo ColomboRenzo Colombo Urology Unit, Università Vita e Salute, Istituto San Raffaele, Milan, Italy , Franco GaddaFranco Gadda Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy , Giacomo GalassoGiacomo Galasso Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy , Andrea LaniaAndrea Lania Endocrinology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy , Juan PalouJuan Palou Urology Unit, Fundacio Puigvert, Barcelona, Spain , Ferran AlgabaFerran Algaba Pathology Unit, Fundacio Puigvert, Barcelona, Spain , Humberto VillavicencioHumberto Villavicencio Urology Unit, Fundacio Puigvert, Barcelona, Spain , Giovanni Maria ColpiGiovanni Maria Colpi Andrology Unit, San Paolo Hospital, Milan, Italy , Ottavio DecobelliOttavio Decobelli Urology Unit, University of Milan, Istituto Europeo di Oncologia, Milan, Italy , Roberto SalvioniRoberto Salvioni Urology Unit, Fondazione Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy , Giorgio PizzocaroGiorgio Pizzocaro Urology Unit, Fondazione Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy , Patrizio RigattiPatrizio Rigatti Urology Unit, Università Vita e Salute, Istituto San Raffaele, Milan, Italy , and Francesco RoccoFrancesco Rocco Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy View All Author Informationhttps://doi.org/10.1016/j.juro.2007.03.108AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We performed a long-term evaluation of conservative surgical treatment of benign Leydig cell tumor. Materials and Methods: A multicenter retrospective clinical study was performed at 6 European centers. Case files of all patients diagnosed with Leydig cell tumor and treated with conservative surgery were examined. Patients underwent physical examination, hormone and tumor marker assays, scrotal and abdominal ultrasound, chest x-ray, and an endocrinological examination. Results: From 1987 to 2006, 22 patients with Leydig cell tumor underwent conservative surgery. Mean patient age was 35 years (range 5 to 61). Mean followup was 47 months (range 1 to 230). No local recurrence or metastasis was observed. Patients presented with a palpable testicular nodule (3 patients, 13.7%) or a nodule diagnosed by ultrasound (15 patients, 68.2%), gynecomastia (2 patients, 9.1%), precocious pseudopuberty (1 patient, 4.5%) or scrotal pain (1 patient, 4.5%). Three patients were monorchid after contralateral orchiectomy for inguinal hernia repair (1 patient, 28 years before surgery) and nonseminomatous germ cell tumor (2 patients, 1 month and 6 years before surgery). Diagnosis after frozen section examination was Leydig cell tumor in 20 of 22 cases (91.0%). Mean histological size of the nodule was 1.11 cm (range 0.5 to 2.5). Preoperative FSH and LH levels were high in 4 patients. Tumor markers were normal before and after surgery. Followup was conducted for all patients every 3 to 6 months with physical examination, tumor markers, scrotal and abdominal ultrasound, chest x-ray. Six patients (27.3%) underwent abdominal computerized tomography. Conclusions: When diagnosed early Leydig cell tumors present a favorable followup. In select cases with motivated patients, conservative surgery proved to be a feasible and safe choice. References 1 : Leydig-Zell-Tumoren des Hodens-Klinische und morphologische Aspekte. Urologe A1996; 35: 468. 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Volume 178Issue 2August 2007Page: 507-511 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsLeydig cell tumorearly diagnosisprognosisMetricsAuthor Information Luca Carmignani Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy More articles by this author Renzo Colombo Urology Unit, Università Vita e Salute, Istituto San Raffaele, Milan, Italy More articles by this author Franco Gadda Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy More articles by this author Giacomo Galasso Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy More articles by this author Andrea Lania Endocrinology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy More articles by this author Juan Palou Urology Unit, Fundacio Puigvert, Barcelona, Spain More articles by this author Ferran Algaba Pathology Unit, Fundacio Puigvert, Barcelona, Spain More articles by this author Humberto Villavicencio Urology Unit, Fundacio Puigvert, Barcelona, Spain More articles by this author Giovanni Maria Colpi Andrology Unit, San Paolo Hospital, Milan, Italy More articles by this author Ottavio Decobelli Urology Unit, University of Milan, Istituto Europeo di Oncologia, Milan, Italy More articles by this author Roberto Salvioni Urology Unit, Fondazione Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy More articles by this author Giorgio Pizzocaro Urology Unit, Fondazione Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy More articles by this author Patrizio Rigatti Urology Unit, Università Vita e Salute, Istituto San Raffaele, Milan, Italy More articles by this author Francesco Rocco Urology Unit, Department of Medicine and Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy More articles by this author Expand All Advertisement PDF downloadLoading ...