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MicroRNAs As Novel Regulators of Angiogenesis

2009; Lippincott Williams & Wilkins; Volume: 104; Issue: 4 Linguagem: Inglês

10.1161/circresaha.108.191270

1524-4571

Yajaira Suárez, William C. Sessa,

Cancer-related molecular mechanisms research

MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.