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Antioxidant activity of new ruthenium compounds

2005; Taylor & Francis; Volume: 10; Issue: 3 Linguagem: Inglês

10.1179/135100005x38897

1743-2928

Marcos Marques da Silva Paula, Claus Tröger Pich, Fabrícia Petronilho, Lilian Batista Drei, Martina Rudnicki, Marcos Roberto de Oliveira, José Cláudio Fonseca Moreira, João Antônio Pêgas Henriques, César Vittorio Franco, Felipe Dal‐Pizzol,

Free Radicals and Antioxidants

Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl2(nic)4] where nic is 3-pyridinecarboxylic acid and trans-[RuCl2(i-nic)4] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 microM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1-10 microM).