Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method
2008; American Society for Microbiology; Volume: 52; Issue: 11 Linguagem: Inglês
10.1128/aac.00420-08
ISSN1098-6596
AutoresLuis Ostrosky‐Zeichner, John Rex, Michael A. Pfaller, Daniel J. Diekema, Barbara D. Alexander, David R. Andes, Steven D. Brown, Vishnu Chaturvedi, Mahmoud A. Ghannoum, Cindy C. Knapp, Daniel J. Sheehan, Thomas J. Walsh,
Tópico(s)Antimicrobial Resistance in Staphylococcus
ResumoWe investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.
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