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Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs

2013; American Association for the Advancement of Science; Volume: 341; Issue: 6142 Linguagem: Inglês

10.1126/science.1239844

1095-9203

Huachen Zhu, D. Wang, David J. Kelvin, Long Li, Zongtai Zheng, Sun‐Woo Yoon, Sook‐San Wong, Amber Farooqui, J. Wang, David W. Banner, R. Chen, Ruifeng Zheng, Jun Zhou, Yulin Zhang, Wei Hong, Wei Dong, Qixu Cai, Michael H. A. Roehrl, Stephen S. H. Huang, Alyson A. Kelvin, Tang Yao, Biao Zhou, X. Chen, GM Leung, Leo L. M. Poon, Robert G. Webster, Richard J. Webby, Malik Peiris, Yi Guan, Yuelong Shu,

Respiratory viral infections research

Avian Flu in Ferrets A recent outbreak of avian H7N9 influenza in humans in eastern China has been closely monitored for any evidence of human-to-human transmission and its potential for sparking a pandemic. Zhu et al. (p. 183 , published online 23 May) examined the behavior of the avian virus in the ferret, a mammalian model for human influenza. The virus was excreted by the ferrets and could be transmitted readily by contact but displayed limited capacity for airborne infectivity. The pathology of H7N9 is similar to H1N1, and it seems that factors other than the intrinsic pathogenicity of the virus contribute to the reported high fatality rate.