Antibody response to rubella virus proteins in different physical forms
1982; Elsevier BV; Volume: 2; Issue: 6 Linguagem: Inglês
10.1016/0166-3542(82)90004-3
ISSN1872-9096
AutoresM. Trudel, Francine Nadon, Robert Comtois, M Ravaoarinoro, Pierre Payment,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoThe immunogenicity of different antigens, containing rubella virus hemagglutinating (HA) membrane protein, was studied using live virus, β-propiolactone-inactivated virus, detergent and lipid-free octamers and virosomes. Whole virus particles, live or inactivated, induced hemagglutination inhibition (HAI) antibodies in rabbits after one subcutaneous injection of 0.16 μg of HA protein. Hemagglutinin rosettes or virosomes failed to induce antibodies even at a dose of 120 μg. Apparently, the extraction of viral membrane hemagglutinin, for the preparation of a rubella subunit vaccine, led to destruction of the antigenicity responsible for the induction of hemagglutination inhibiting antibodies. These results are discussed in the light of earlier studies on the preparation of a rubella subunit vaccine.
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