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Applications of OralCDx methodology in the diagnosis of oral leukoplakia

2012; Medicina Oral S.L.; Linguagem: Inglês

10.4317/medoral.17275

1698-6946

Flavio Seijas‐Naya, T. Garcia-Carnicero, Pilar Gándara Vila, E. Couso-Folgueiras, Mario Pérez‐Sayáns, R. Gandara-Vila, Abel Garcı́a Garcı́a, JM. Gandara-Rey,

Oral and gingival health research

Objective: We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a "potentially malignant disorder" such as oral leukoplakia.Design of the study: We performed a study in which samples were taken using OralCDx ® on 24 patients who visited the Master of Oral Medicine, Oral Surgery and Implantology of the University of Santiago de Compostela between February 2009 and May 2010.These patients presented clinical and histological lesions that were consistent with oral leukoplakia.We evaluated the relationship between the keratinization degree of the lesions and cell representation; the diagnosis obtained through OralCDx ® and biopsies; and sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).Results: 50% of patients were men and 50% women with an average age of 62.38 years.The Kappa coefficient relating keratinization of lesions and cell representation was 0.33, the OralCDx ® -biopsy diagnostic rate reached a Kappa value of 0.66, recording 72.7%,