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BIBTEX RIS

MMP-9 and -12 cause N-cadherin shedding and thereby β-catenin signalling and vascular smooth muscle cell proliferation

2008; Oxford University Press; Volume: 81; Issue: 1 Linguagem: Inglês

10.1093/cvr/cvn278

ISSN

1755-3245

Autores

Amrita Dwivedi, Sadie C. Slater, Sarah J. George,

Tópico(s)

Signaling Pathways in Disease

Resumo

AimsVascular smooth muscle cell (VSMC) proliferation contributes to intimal thickening in restenosis and atherosclerosis. Previously, we demonstrated that matrix-degrading metalloproteinase (MMP)-dependent shedding of the extracellular portion of N-cadherin increased VSMC proliferation via elevation of β-catenin signalling and cyclin D1 expression. In this study, we aimed to determine whether MMP-2, -9, -12, or -14 regulates VSMC proliferation via N-cadherin shedding.

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