Portal de Periódicos da CAPES

SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women

2013; Informa; Volume: 32; Issue: 4 Linguagem: Inglês

10.3109/10641955.2013.810237

1525-6065

Martin Kolísek, Carlos Galaviz‐Hernández, Fernando Vázquez-Alaníz, Gerhard Sponder, Saba Javaid, Katharina Kurth, Axel Nestler, Martha Rodrı́guez-Morán, Stefan Verlohren, Fernando Guerrero‐Romero, Jörg R. Aschenbach, Jürgen Vormann,

Birth, Development, and Health

Objective: To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. Methods: The expression profiles of MRGs were determined in placentas of normoevolutive (N = 26) and preeclamptic (N = 25) women by RT-qPCR. Results: Among all tested MRGs (9) only SLC41A1 (encoding for Na+/Mg2+ exchanger) was significantly overexpressed in ∼54.2% of preeclamptic (n = 24) and in ∼9.5% of normoevolutive (n = 21) specimens. On average, SLC41A1 was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. Conclusion. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.