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Activity patterns of catecholamine‐containing pontine neurons in the dorso‐lateral tegmentum of unrestrained cats

1974; Wiley; Volume: 5; Issue: 6 Linguagem: Inglês

10.1002/neu.480050605

1097-4695

Nai‐Shin Chu, Floyd E. Bloom,

Neuroscience and Neuropharmacology Research

Abstract Single catecholamine‐containing neurons in the dorso‐lateral pontine tegmentum were recorded in unanesthetized, freely behaving cats. Microscopic lesions were made on each recorded unit and subsequently identified for catecholamines by fluorescence histochemical analysis. The majority of the NE‐containing neurons exhibited low spontaneous discharge rates in quiet wakefulness and in slow wave sleep. In paradoxical sleep, the medially located NE‐containing neurons tend to exhibit ursting discharges which are closely related to individual PGO waves. The laterally or dorsally situated NE units fire more slowly and tend to derease their firing activity during paradoxical sleep. Tonically active, relatively fast NE‐containing units were also found. Often, those neurons showed greatly increased activity before the cat awoke from either slow wave sleep or paradoxical sleep, with activity persisting during the early moments of waking. The combination of histochemical and electrophysiologic methods proved essential for correlating neurochemistry and function within the heterogeneous NE‐containing nuclei of the cat pons.