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Effectiveness of Mass Oral Cholera Vaccination in Beira, Mozambique

2005; Massachusetts Medical Society; Volume: 352; Issue: 8 Linguagem: Inglês

10.1056/nejmoa043323

1533-4406

Marcelino Lucas, Jacqueline Deen, Lorenz von Seidlein, Xuan-Yi Wang, Julia S. Ampuero, Mahesh Puri, Mohammad Ali, M. Ansaruzzaman, Juvenaldo Amos, Arminda Macuamule, Philippe Cavailler, Philippe J. Guérin, Claude Mahoudeau, Pierre Kahozi-Sangwa, Claire‐Lise Chaignat, Avertino Barreto, Francisco Songane, John D. Clemens,

COVID-19 epidemiological studies

New-generation, orally administered cholera vaccines offer the promise of improved control of cholera in sub-Saharan Africa. However, the high prevalence of human immunodeficiency virus (HIV) infection in many cholera-affected African populations has raised doubts about the level of protection possible with vaccination. We evaluated a mass immunization program with recombinant cholera-toxin B subunit, killed whole-cell (rBS-WC) oral cholera vaccine in Beira, Mozambique, a city where the seroprevalence of HIV is 20 to 30 percent.