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BIBTEX RIS

A Concise Synthesis of (−)‐Oseltamivir

2008; Wiley; Volume: 47; Issue: 20 Linguagem: Inglês

10.1002/anie.200800282

ISSN

1521-3773

Autores

Barry M. Trost, Ting Zhang,

Tópico(s)

Catalytic C–H Functionalization Methods

Resumo

Tackling the supply problem: A short and efficient synthesis of (−)-oseltamivir has been developed which requires eight steps from commercially available starting material and proceeds with an overall yield of 30 %. Key transformations include a novel palladium-catalyzed asymmetric allylic alkylation reaction (Pd-AAA, see scheme) as well as a chemo-, regio-, and stereoselective aziridination reaction. Phth=phthaloyl.

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