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Delayed Orchiectomy After Chemotherapy for Metastatic Nonseminomatous Germ Cell Tumors

1996; Lippincott Williams & Wilkins; Volume: 155; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(01)66355-9

1527-3792

Ilan Leibovitch, J. Samuel Little, Richard S. Foster, Randall G. Rowland, Richard Bihrle, John P. Donohue,

Sperm and Testicular Function

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1996Delayed Orchiectomy After Chemotherapy for Metastatic Nonseminomatous Germ Cell Tumors Ilan Leibovitch, J. Samuel Little, Richard S. Foster, Randall G. Rowland, Richard Bihrle, and John P. Donohue Ilan LeibovitchIlan Leibovitch More articles by this author , J. Samuel LittleJ. Samuel Little More articles by this author , Richard S. FosterRichard S. Foster More articles by this author , Randall G. RowlandRandall G. Rowland More articles by this author , Richard BihrleRichard Bihrle More articles by this author , and John P. DonohueJohn P. Donohue More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66355-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We reviewed current experience at our university with delayed orchiectomy after chemotherapy in patients with metastatic nonseminomatous germ cell tumors. Materials and Methods: We retrospectively analyzed the records of 160 patients with metastatic germ cell cancer who were given systemic chemotherapy, and subsequently underwent orchiectomy and retroperitoneal lymph node dissection. Results: Analysis of 160 testicular specimens revealed necrosis or scar in 70 (43.7 percent), pure teratoma in 50 (31.2 percent) and persistent germ cell cancer in 40 (25 percent). Corresponding incidences of histopathological findings in the post-chemotherapy retroperitoneal lymph node dissection specimens were significantly different, correlating with less than half of the cases (chi-square, p = 0.002). Conclusions: Our study confirms the need for delayed orchiectomy after systemic chemotherapy even when there seems to be a partial or complete clinical response at other sites. References 1 : Surgery of testicular neoplasms. In: . Philadelphia: W. B. Saunders Co.1992: 3090. chapt. 86. Google Scholar 2 : Review of delayed orchiectomy in patients with disseminated testis tumors. J. Urol.1983; 129: 522. Link, Google Scholar 3 : Pathologic findings at orchiectomy following chemotherapy for disseminated testicular cancer. J. Clin. Oncol.1984; 2: 1025. Google Scholar 4 : Orchiectomy in advanced germ cell cancer following intensive chemotherapy: a comparison of systemic to testicular response. J. Urol.1986; 136: 1221. 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Google Scholar 19 : Heterogeneity in growth pattern and drug sensitivity of primary tumor and metastases in the human tumor colony-forming assay. Cancer Res.1982; 42: 4086. Google Scholar 20 : Human tumor cell heterogeneity and metastasis. J. Clin. Oncol.1983; 1: 496. Google Scholar 21 : Testicular ultrasonography after chemotherapy for germ cell neoplasm: significance of highly hyperechoic lesions. Urology1992; 39: 490. Google Scholar Department of Urology, Indiana University Medical Center, Indianapolis, Indiana© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by (2018) RE: ORGAN SPARING SURGERY FOR MALIGNANT GERM CELL TUMOR OF THE TESTIS: Reply by AuthorsJournal of Urology, VOL. 168, NO. 3, (1111-1112), Online publication date: 1-Sep-2002. Volume 155Issue 3March 1996Page: 952-954 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Ilan Leibovitch More articles by this author J. Samuel Little More articles by this author Richard S. Foster More articles by this author Randall G. Rowland More articles by this author Richard Bihrle More articles by this author John P. Donohue More articles by this author Expand All Advertisement PDF downloadLoading ...