Portal de Periódicos da CAPES

Granulocyte‐macrophage colony stimulating factor for the treatment of drug induced agranulocytosis

1991; Wiley; Volume: 37; Issue: 4 Linguagem: Inglês

10.1002/ajh.2830370411

1096-8652

Sucha Nand, Robert Bayer, Richard A. Prim, William Felten, John E. Godwin,

Acute Myeloid Leukemia Research

Abstract Drug induced agranulocytosis is an uncommon but potentially fatal complication. In some cases, it may be associated with hypoplasia and depletion of granulocytic precursors in the marrow, leading to prolonged neutropenia. We report on the use of granulocytic‐macrophage colony stimulating factor (GM‐CSF) in two such cases, at a dose of 10 μg per kilogram per day subcutaneously. The absolute neutrophil count rose above 500/mm 3 in 3 days in both cases. We believe that GM‐CSF expedited the recovery of granulocyte counts in our patients and warrants further study in the management of drug induced neutropenia.