Chiral N,N′-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis
2014; Royal Society of Chemistry; Volume: 1; Issue: 3 Linguagem: Inglês
10.1039/c3qo00059a
ISSN2052-4129
AutoresXiaohua Liu, Lili Lin, Xiaoming Feng,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA class of conformationally flexible ligands composed of a tertiary amino oxide–amide backbone and a straight-chain alkyl spacer was developed. These C2-symmetric chiral N,N′-dioxide ligands could be straightforwardly synthesized from readily available amino acids and amines. They act as neutral tetradentate ligands to bind a wide variety of metal ions. Non-planar cis-α M(N,N′-dioxide) complexes enable an intriguing and easily fine-tuned chiral platform for a number of asymmetric reactions. Privileged N,N′-dioxide ligands frequently show wide substrate generality and exceptional levels of stereocontrol for a specific catalytic reaction. We describe approaches to the ligand design and synthesis, structure and bonding in coordination complexes, and the recent developments in asymmetric catalysis.
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