Interleukin-8 and CXCR1 Receptor Functional Polymorphisms and Susceptibility to Acute Pyelonephritis
2007; Lippincott Williams & Wilkins; Volume: 177; Issue: 3 Linguagem: Inglês
10.1016/j.juro.2006.10.037
ISSN1527-3792
AutoresLina Artifoni, Susanna Negrisolo, Giovanni Montini, Pietro Zucchetta, Pier Paolo Molinari, Walburga Cassar, R Destro, Franca Anglani, Waifro Rigamonti, Graziella Zacchello, Luisa Murer,
Tópico(s)Immune Response and Inflammation
ResumoNo AccessJournal of UrologyPediatric urology1 Mar 2007Interleukin-8 and CXCR1 Receptor Functional Polymorphisms and Susceptibility to Acute Pyelonephritis Lina Artifoni, Susanna Negrisolo, Giovanni Montini, Pietro Zucchetta, Pier Paolo Molinari, Walburga Cassar, Roberta Destro, Franca Anglani, Waifro Rigamonti, Graziella Zacchello, and Luisa Murer Lina ArtifoniLina Artifoni More articles by this author , Susanna NegrisoloSusanna Negrisolo More articles by this author , Giovanni MontiniGiovanni Montini More articles by this author , Pietro ZucchettaPietro Zucchetta More articles by this author , Pier Paolo MolinariPier Paolo Molinari More articles by this author , Walburga CassarWalburga Cassar More articles by this author , Roberta DestroRoberta Destro More articles by this author , Franca AnglaniFranca Anglani More articles by this author , Waifro RigamontiWaifro Rigamonti More articles by this author , Graziella ZacchelloGraziella Zacchello More articles by this author , and Luisa MurerLuisa Murer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.10.037AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We performed a case-control study in children diagnosed by the first episode of upper urinary tract infection with or without vesicoureteral reflux to evaluate the association of functional polymorphism of interleukin-8 (−251A>T and +2767A>G), and its receptor CXCR1 (+2607G>C). Materials and Methods: Genomic DNA was obtained from 265 children with a clinical and laboratory diagnosis of urinary tract infection who were recruited in northeast Italy. The children were subdivided as 173 who were dimercapto-succinic acid scan positive with positive static renal scintigraphy in acute conditions, consistent with the diagnosis of acute pyelonephritis, and 92 who were dimercapto-succinic acid scan negative. Genetic analysis for the same polymorphisms was also extended to a control population of 106 umbilical cord DNA samples. Results: Statistical analysis of genotype data showed that 1) the tested populations were in Hardy-Weinberg equilibrium, 2) there were significant differences between the dimercapto-succinic acid scan positive and negative groups (p = 0.049), and the dimercapto-succinic acid scan positive group vs controls (p = 0.032) in terms of interleukin-8 −251A>T polymorphism frequency, 3) there was also a significant difference in the distribution of IL-8 −251A>T and +2767A>G polymorphisms between dimercapto-succinic acid scan positive and negative children in the subgroup without vesicoureteral reflux (p = 0.03 and 0.02, respectively) and 4) no significant differences were found in the frequency of the distribution of CXCR1 +2607G>C polymorphism in all groups. Conclusions: These data suggest that the gene for the proinflammatory chemokine interleukin-8 is involved in susceptibility to acute pyelonephritis during upper urinary tract infection in children with or without vesicoureteral reflux. 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Volume 177Issue 3March 2007Page: 1102-1106 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordspyelonephritisurinary tractchemokinesgeneticpolymorphismurinary tract infectionsMetricsAuthor Information Lina Artifoni More articles by this author Susanna Negrisolo More articles by this author Giovanni Montini More articles by this author Pietro Zucchetta More articles by this author Pier Paolo Molinari More articles by this author Walburga Cassar More articles by this author Roberta Destro More articles by this author Franca Anglani More articles by this author Waifro Rigamonti More articles by this author Graziella Zacchello More articles by this author Luisa Murer More articles by this author Expand All Advertisement PDF downloadLoading ...
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