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Endemic Tegumentary Leishmaniasis in Brazil: Correlation between Level of Endemicity and Number of Cases of Mucosal Disease

2011; American Society of Tropical Medicine and Hygiene; Volume: 84; Issue: 6 Linguagem: Inglês

10.4269/ajtmh.2011.10-0595

1476-1645

Sandro Javier Bedoya-Pacheco, Maria Helena de Araújo-Melo, Cláudia Maria Valete‐Rosalino, Maria Inês Fernandes Pimentel, Fátima Conceição‐Silva, Armando O. Schubach, M. C. A. Marzochi,

Trypanosoma species research and implications

The purpose of this study was to establish a correlation between the endemic level of tegumentary leishmaniasis in different regions of Brazil during 2002–2009 and the number of cases of mucosal or mucocutaneous leishmaniasis. The proportion of mucosal leishmaniasis was inversely correlated with prevalence of infection. In areas with a lower infection prevalence, the proportion of mucosal leishmaniasis increased ( P < 0.05). The hypothesis of an Amazonian origin and dissemination through human migration is considered. Our results show that in regions with lower prevalence and endemically younger, the proportion of cases that evolve to the mucosal form is higher than in regions with higher prevalence and endemically older.