Extra- and intracellular antimycobacterial activity of Arbutus unedo L.
2012; Academic Journals; Volume: 6; Issue: 6 Linguagem: Inglês
10.5897/ajmr11.1540
ISSN1996-0808
AutoresEl ouarti Asmae, Cherif Haouat Amina, Sqalli Hakima, Abdellatif Haggoud, Abdeslam Ennabili, Saâd Ibnsouda Koraichi, lachgar Mohamed, Mohammed Iraqui,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoThis study aims to evaluate extra- and intracellullar antimycobacterial activity of Arbutus unedo L. leaves-extracts. We tested the aqueous and ethanol extracts of Arbutus leaves effect against three mycobacteria growth, and showed that aqueous extract and the part I of ethanol extract have a remarkable extracellular antimycobacterial activity. The MIC (Minimum inhibitory concentration) of the part I of ethanol extract is 5.59 ± 0.69 mg/ml forMycobacterium aurum A + and 6.02 ± 0.76 mg/ ml for Mycobacterium smegmatis MC2and Mycobacterium bovis PPI. The part I of arbutus ethanol-extract, used at 6.02 ± 0.76 mg/ml, has a bactericidal effect on M. smegmatis MC2 located within the rat peritoneal macrophages. Key words: Antimycobacterial activity, Arbutus unedo L., rat peritoneal macrophages.
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