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Controlled Iterative Cross‐Coupling: On the Way to the Automation of Organic Synthesis

2009; Wiley; Volume: 48; Issue: 29 Linguagem: Inglês

10.1002/anie.200901680

1521-3773

Congyang Wang, Frank Glorius,

Catalytic Cross-Coupling Reactions

Abstract Repetition does not hurt! New strategies for the modulation of the reactivity of difunctional building blocks are discussed, allowing the palladium‐catalyzed controlled iterative cross‐coupling and, thus, the efficient formation of complex molecules of defined size and structure (see scheme). As in peptide synthesis, this development will enable the automation of these reactions. M PG =protected metal, M act =metal. magnified image