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Acanthamoeba polyphaga Mimivirus Prevents Amoebal Encystment-Mediating Serine Proteinase Expression and Circumvents Cell Encystment

2014; American Society for Microbiology; Volume: 89; Issue: 5 Linguagem: Inglês

10.1128/jvi.03177-14

ISSN

1098-5514

Autores

Paulo Victor de Miranda Boratto, Jonas D. Albarnaz, Gabriel Magno de Freitas Almeida, Lucas Magno Rocha Botelho, Alide Caroline Lima Fontes, Adriana Oliveira Costa, Daniel Assis Santos, Cláudio Antônio Bonjardim, Bernard La Scola, Erna Geessien Kroon, Jônatas Santos Abrahão,

Tópico(s)

Bacillus and Francisella bacterial research

Resumo

Acanthamoeba is a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus, Acanthamoeba polyphaga mimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.

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